Results 211 to 220 of about 1,085,849 (268)

Single-molecule neuromorphic device with aJ-level power consumption per switching. [PDF]

Nat Commun
Zhang H, Ye J, Gao M, Yan C, Jiang Y, Zhang B, Zhou Y, Shang W, Chen L, Wu J, Li Z, Zeng T, Xu W, Li X, Bai J, Li J, Zhang Y, Xiao Z, Shi J, Zhang G, Liu J, Zhang D, Hong W.   +22 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

autoFISH: a modular toolbox for sequential single-molecule RNA FISH experiments. [PDF]

Commun Biol
Weber C, Defard T, Sturmach C, Lelek M, Laporte H, Mallick A, Gariboldi MI, Londoño-Vallejo JA, Walter T, Fouillade C, Bourg J, Mueller F.   +11 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Objective clustering protocol for single-molecule data: A lifetime vs. intensity study. [PDF]

Biophys Rep (N Y)
Lovemore MAC, van Heerden B, Botha JL, Krüger TPJ.   +3 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

ErbB family receptor dimerization dynamics and dysregulation via long-term single-molecule imaging. [PDF]

Cell
Ma K, Ma X, Shida JF, Niu Z, Lin YK, Mandal S, Dobbins A, Golomb L, Eck MJ, Greulich H, Meyerson M, Peng CS.   +11 more
europepmc   +1 more source

Bridging single-molecule and genome-wide studies of cellular mRNA translation. [PDF]

RNA
Koch A, Tomuro K, Wakigawa T, Morisaki T, Iwasaki S, Stasevich TJ.   +5 more
europepmc   +1 more source

Characterizing the Impact of Nucleoid-Associated Proteins on HU-DNA Interactions by Live-Cell Single-Molecule Tracking. [PDF]

Chemphyschem
Fuller DEH, Dai X, McCarthy LA, Way LE, Wang X, Biteen JS.   +5 more
europepmc   +1 more source

Contrasting single-molecule magnet behaviour in dysprosium and terbium bis(stannolediide) complexes. [PDF]

Nat Chem
Sun X, Hinz A, Maier S, Gillhuber S, Jin D, Saito M, Weigend F, Schlittenhardt S, Moreno-Pineda E, Wernsdorfer W, Ruben M, Roesky PW.   +11 more
europepmc   +1 more source