Results 91 to 100 of about 7,224,188 (257)

Application of ionic liquids in single-molecule junctions: Recent advances and prospects

Green Energy & Environment
Single-molecule junctions, integrating individual molecules as active components between electrodes, serve as fundamental building blocks for advanced electronic and sensing technologies.
Li Zhou, Miao Zhang, Yani Huo, Liping Bai, Suhang He, Jinying Wang, Chuancheng Jia, Xuefeng Guo   +7 more
doaj   +1 more source

Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate

Nature Communications, 2016
The Cdc45-MCM-GINS (CMG) helicase unwinds DNA during replication, a process that requires the ATPase-dependent activity of the MCM complex. Using cryo-EM reconstructions of the CMG complex in different conformations, the authors propose a model where the
Ferdos Abid Ali, Ludovic Renault, Julian Gannon, Hailey L. Gahlon, Abhay Kotecha, Jin Chuan Zhou, David Rueda, Alessandro Costa   +7 more
doaj   +1 more source

High-Speed Single-Molecule Tracking of CXCL13 in the B-Follicle

Frontiers in Immunology, 2018
Soluble factors are an essential means of communication between cells and their environment. However, many molecules readily interact with extracellular matrix components, giving rise to multiple modes of diffusion.
Helen Miller, Helen Miller, Jason Cosgrove, Jason Cosgrove, Jason Cosgrove, Adam J. M. Wollman, Adam J. M. Wollman, Emily Taylor, Emily Taylor, Zhaokun Zhou, Zhaokun Zhou, Peter J. O’Toole, Peter J. O’Toole, Mark C. Coles, Mark C. Coles, Mark C. Coles, Mark C. Leake, Mark C. Leake   +17 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Incoherent x-ray scattering in single molecule imaging

New Journal of Physics, 2014
Imaging of the structure of single proteins or other biomolecules with atomic resolution would be enormously beneficial to structural biology. X-ray free-electron lasers generate highly intense and ultrashort x-ray pulses, providing a route towards ...
J M Slowik, S-K Son, G Dixit, Z Jurek, R Santra   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Quantification of Receptor Targeting Aptamer Binding Characteristics Using Single-Molecule Spectroscopy [PDF]

, 2011
This experimental design presents a single molecule approach based on fluorescence correlation spectroscopy (FCS) for the quantification of outer membrane proteins which are receptors to an aptamer specifically designed to target the surface receptors of
Brittany Book, Book, Brittany, Joseph Irudayaraj, Chen, Jiji, Irudayaraj, Joseph, Jiji Chen   +5 more
core   +1 more source

Single-molecule microscopy study of nano-systems [PDF]

, 2011
In this work, techniques were developed and used to study the properties of molecules on a single-molecule level. Single-molecule techniques have the major advantage, that in contrast to ensemble measurements, they allow a detailed insight on the ...
Heiss, Gregor
core   +1 more source

Precise intracellular uptake and endosomal release of diverse functional mRNA payloads via glutathione-responsive nanogels

Materials Today Bio
We present a novel, highly customizable glutathione-responsive nanogel (NG) platform for efficient mRNA delivery with precise mRNA payload release control.
Rupali Dabas, Naveenan Navaratnam, Haruki Iino, Saidbakhrom Saidjalolov, Stefan Matile, David Carling, David S. Rueda, Nazila Kamaly   +7 more
doaj   +1 more source