Results 81 to 90 of about 308,535 (321)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Quantum phase interference (Berry phase) in single-molecule magnets of Mn12

, 2001
Magnetization measurements of a molecular clusters Mn12 with a spin ground state of S = 10 show resonance tunneling at avoided energy level crossings. The observed oscillations of the tunnel probability as a function of the magnetic field applied along ...
Aubin, Barnes, Caneschi, Chudnovsky, D. N. Hendrickson, G. Christou, Garg, Garg, Garg, Garg, Garg, Jin, Kececiolu, Landau, Leuenberger, Leuenberger, Liang, Lü, Lü, Lü, M. Soler, Soler, Villain, W. Wernsdorfer, Wernsdorfer, Wernsdorfer, Wernsdorfer, Wernsdorfer, Yoo, Yoo, Zener, Zhang   +31 more
core   +2 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Ferromagnetic Oxime-Based Manganese(III) Single-Molecule Magnets with Dimethylformamide and Pyridine as Terminal Ligands

Crystals, 2018
Two new members of the [Mn6] family of single-molecule magnets (SMMs) of formulae [Mn6(μ3-O)2(H2N-sao)6(dmf)8](ClO4)2 (1) and [Mn6(μ3-O)2(H2N-sao)6(py)6(EtOH)2][ReO4]2·4EtOH (2), (dmf = N,N′-dimethylformamide, py = pyridine, H2N-saoH2 =
Carlos Rojas-Dotti, Nicolás Moliner, Francesc Lloret, José Martínez-Lillo   +3 more
doaj   +1 more source

Exploring the magnetic properties of the largest single molecule magnets [PDF]

, 2020
The giant {Mn₇₀} and {Mn₈₄} wheels are the largest nuclearity single-molecule magnets synthesized to date, and understanding their magnetic properties poses a challenge to theory.
Chan, Garnet K.-L., Chen, Dianteng, Cheng, Hai-Ping, O'Rourke, Matthew J., Schurkus, Henry F.   +4 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Quantum phase interference and spin parity in Mn12 single-molecule magnets

, 2005
Magnetization measurements of Mn12 molecular nanomagnets with spin ground states of S = 10 and S = 19/2 showresonance tunneling at avoided energy level crossings.
A. Garg, C. Zener, G. Christou, H. A. Kramers, J. L. Van Hemmen, L. Landau, N. E. Chakov, W. Wernsdorfer, W. Wernsdorfer   +8 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

MAGNEŢI MOLECULARI – TRECEREA DE LA LIGANZI DE TIP SALEN SPRE TIOSEMICARBAZONE

Studia Universitatis Moldaviae: Stiinte reale si ale naturii, 2016
Au fost scoşi în evidenţă compuşi coordinativi ai manganului(III) cu liganzi tip Salen ce posedă proprietăţi de magneţi moleculari (SMM) sau lanţuri magnetice (SCM).
Mihail SECU
doaj  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source