Results 281 to 290 of about 1,653,696 (343)

Association of single-nucleotide polymorphisms in SLC2A9, SLC22A12 and SLC22A11 genes with hyperuricemia in the Chinese Tibetan population. [PDF]

Medicine (Baltimore)
Li RX, Guo YN, Wang J, Luo B, Danzen G, Zhang T.   +5 more
europepmc   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

The genetic diversity and populational specificity of the human gut virome at single-nucleotide resolution. [PDF]

Microbiome
Wang X, Dong Q, Huang P, Yang S, Gao M, Zhang C, Zhang C, Deng Y, Huang Z, Ma B, Jiao Y, Zhou Y, Wu T, Zou H, Shi J, Sheng Y, Wang Y, Consortium C, Tang L, Hu S, Duan Y, Sun W, Chen W, Zhai Q, Kong X, Chen L.   +25 more
europepmc   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Clinical application of single nucleotide polymorphism array in prenatal diagnosis: Experience with 8753 samples. [PDF]

PLoS One
Wen L, Zhang Y, Zhang W, Mao A, Li X.
europepmc   +1 more source

The impact of asparaginase phenotype-related single nucleotide polymorphisms on prognosis in pediatric B-cell precursor acute lymphoblastic leukemia. [PDF]

Eur J Med Res
Zhang J, Xu C, Qin J, Shen D, Liu L, Xia T, Xu X.   +6 more
europepmc   +1 more source

Nanopore detection of single-nucleotide RNA mutations and modifications with programmable nanolatches. [PDF]

Nat Nanotechnol
Li Y, Meng SC, Wang Y, Platnich CM, Earle MK, Mylona E, Naydenova P, Baker S, Zhu J, Keyser UF.   +9 more
europepmc   +1 more source

<i>RAPSN</i>-Associated Congenital Myasthenic Syndrome due to Biallelic Single Nucleotide Variants at the Same Position. [PDF]

Case Rep Genet
Keehan L, Carter JN, Kravets E, Wheeler MT, Bernstein JA, Maselli RA, Sampson JB, Bachir S.   +7 more
europepmc   +1 more source

A centenarian single nucleotide polymorphism in collagen gene COL25A1 promotes longevity in C. elegans. [PDF]

NPJ Aging
Goyala A, Statzer C, Park JYC, Neundorf I, MacArthur MR, Gebauer JM, Ewald CY.   +6 more
europepmc   +1 more source

Association of ficolin single nucleotide polymorphism with systemic lupus erythematosus in the Chinese Han Population. [PDF]

Rheumatol Immunol Res
Yin F, Gu J, Zhao P, Chen J.
europepmc   +1 more source