Results 71 to 80 of about 1,522,500 (352)

Integrated Human Skin Bacteria Genome Catalog Reveals Extensive Unexplored Habitat‐Specific Microbiome Diversity and Function

Advanced Science, 2023
The skin is the largest organ in the human body. Various skin environments on its surface constitutes a complex ecosystem. One of the characteristics of the skin micro‐ecosystem is low biomass, which greatly limits a comprehensive identification of the ...
Zhiming Li, Yanmei Ju, Jingjing Xia, Zhe Zhang, Hefu Zhen, Xin Tong, Yuzhe Sun, Haorong Lu, Yang Zong, Peishan Chen, Kaiye Cai, Zhen Wang, Huanming Yang, Jiucun Wang, Jian Wang, Yong Hou, Xin Jin, Tao Zhang, Wenwei Zhang, Xun Xu, Liang Xiao, Ruijin Guo, Chao Nie   +22 more
doaj   +1 more source

Genome sequencing of a Hevea brasiliensis for single nucleotide polymorphism discovery [PDF]

, 2013
The rubber tree (Hevea spp.), is the primary plant used in natural rubber production. Historically, the breeding of rubber trees has been based on techniques involving statistics and quantitative genetic approaches to determine the best genotypes to be ...
Cardoso-Silva, Claudio Benicio, Conson, Andre R.O., Garcia, Antonio Augusto Franco, Le Guen, Vincent, Mantello, Camilia Campos, Silva, Carla Cristina, Souza, Anete Pereira, Souza, Livia Moura, Toledo-Silva, Guilherme   +8 more
core  

InPhaDel: integrative shotgun and proximity-ligation sequencing to phase deletions with single nucleotide polymorphisms. [PDF]

, 2016
Phasing of single nucleotide (SNV), and structural variations into chromosome-wide haplotypes in humans has been challenging, and required either trio sequencing or restricting phasing to population-based haplotypes.
Bafna, Vineet, Bansal, Vikas, Edge, Peter, Patel, Anand, Selvaraj, Siddarth   +4 more
core   +2 more sources

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

The combination of Ile225Thr polymorphism of Fcg receptor IIB gene and hypersensitiveness as risk factor for human systemic lupus erythematosus in chinese populations

Indian Journal of Dermatology, 2007
Background: The aim of this study was to investigate the role of FcgRIIB gene in susceptibility to systemic lupus erythematosus (SLE) using family-based association study and to examine possible interaction between the Ile225Thr (rs1050501, exon 5 ...
Pan Faming, Ye Dongqing, Zhang Kechun, Li Xiangpei, Xu Jianhua, Chen Hong, Su Hong   +6 more
doaj  

The Biological Influence and Clinical Relevance of Polymorphism Within the NKG2D Ligands

Frontiers in Immunology, 2018
NKG2D is a major regulator of the activity of cytotoxic cells and interacts with eight different ligands (NKG2DL) from two families of MIC and ULBP proteins.
Jianmin Zuo, Fiyaz Mohammed, Paul Moss
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Loneliness in Relation to Depression: The Moderating Influence of a Polymorphism of the Brain Derived Neurotrophic Factor Gene on Self-efficacy and Coping Strategies

Frontiers in Psychology, 2017
Disturbances of brain derived neurotrophic factor (BDNF) signaling, which may occur among those with a polymorphism of the Val66Met gene, comprising a Met substitution for the Val allele, may be associated with depressive cognitions.
Marc Bedard, Robbie Woods, Carly Crump, Hymie Anisman   +3 more
doaj   +1 more source

Single-Nucleotide Polymorphisms in the p53 Pathway [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2005
A cell culture assay has been developed that detects and validates single-nucleotide polymorphisms (SNPs) in genes that populate the p53 pathway. One hundred thirteen EBV-transformed human B-lymphocyte cell lines obtained from a diverse population were employed to measure the apoptotic response to gamma radiation.
Z. Feng, Angelica K. Teresky, Wenwei Hu, X. Yu, S.L. Harris, Elisabeth E. Bond, K. Hirshfield, G. Gil, Harlan Robins, Gareth L. Bond, Arnold J. Levine   +10 more
openaire   +3 more sources

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source