Results 11 to 20 of about 715,579 (403)

A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation

Science, 2022
Establishing causal links between inherited polymorphisms and cancer risk is challenging. Here, we focus on the single-nucleotide polymorphism rs55705857, which confers a sixfold greater risk of isocitrate dehydrogenase (IDH)–mutant low-grade glioma (LGG)
C. Yanchus, K. Drucker, T. Kollmeyer, R. Tsai, M. Liang, L. Jiang, J. Pawling, A. Ali, P. Decker, M. Kosel, A. Panda, A. Malik, K. Al-Zahrani, J. Hernandez, M. Ahmed, S. Loganathan, D. Trcka, A. Michaelraj, J. Fortin, P. Mazrooei, L. Zhou, A. Elia, M. Lupien, H. He, L. Wang, A. Abyzov, J. Dennis, M. Wilson, J. Wrana, D. Lachance, M. Wrensch, J. Wienck, L. Pennacchio, D. Dickel, A. Visel, M. Taylor, G. Zadeh, P. Dirks, J. E. Eckel Passow, T. Mak, E. Kvon, R. Jenkins, D. Schramek   +42 more
semanticscholar   +1 more source

Genomic diversity affects the accuracy of bacterial single-nucleotide polymorphism–calling pipelines

GigaScience, 2020
Background Accurately identifying single-nucleotide polymorphisms (SNPs) from bacterial sequencing data is an essential requirement for using genomics to track transmission and predict important phenotypes such as antimicrobial resistance.
Stephen J. Bush, D. Foster, D. Eyre, Emily L. Clark, Nicola De Maio, Liam P. Shaw, N. Stoesser, T. Peto, D. W. Crook, A. Walker   +9 more
semanticscholar   +1 more source

Association of the leptin receptor Q223R (rs1137101) polymorphism with obesity measures in Sri Lankans [PDF]

, 2020
OBJECTIVE: The role of genetic factors in the development of obesity is largely unreported in Sri Lankans. The Q223R (rs1137101) single nucleotide polymorphism (SNP) of the leptin receptor (LEPR) gene has been associated with obesity measures in various ...
Dalton, C.F., Fernando, D.J., Illangasekera, Y.A., Kumarasiri, P.V.R.   +3 more
core   +1 more source

Association between SORL1 polymorphisms and the risk of Alzheimer's disease [PDF]

Journal of Integrative Neuroscience, 2018
A meta-analysis was performed to identify empirical data assessing the effects of a single nucleotide polymorphisms of sortilin-related receptor on Alzheimer's disease based on 14 studies involving 37941 cases and 49727 control studies. Analysis showed, (
Lele Cong, Xiangyi Kong, Jing Wang, Jianshi Du, Zhongxin Xu, Yanan Xu, Qing Zhao
doaj   +1 more source

Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array

Plant Biotechnology Journal, 2014
High-density single nucleotide polymorphism (SNP) genotyping arrays are a powerful tool for studying genomic patterns of diversity, inferring ancestral relationships between individuals in populations and studying marker–trait associations in mapping ...
Shichen Wang, Debbie Wong, K. Forrest, A. Allen, S. Chao, B. Huang, M. Maccaferri, S. Salvi, S. Milner, L. Cattivelli, A. Mastrangelo, A. Whan, S. Stephen, G. Barker, Ralf Wieseke, J. Plieske, International Wheat Genome Sequencing Consortium, M. Lillemo, D. Mather, R. Appels, R. Dolferus, G. Brown-Guedira, A. Korol, Alina Akhunova, C. Feuillet, J. Salse, M. Morgante, C. Pozniak, M. Luo, J. Dvorak, M. Morell, J. Dubcovsky, M. Ganal, R. Tuberosa, C. Lawley, Ivan Mikoulitch, C. Cavanagh, K. Edwards, M. Hayden, E. Akhunov   +39 more
semanticscholar   +1 more source

Impact of the Polymorphism of the PACRG and CD80 Genes on the Development of the Different Stages of Tuberculosis Infection [PDF]

Iranian Journal of Medical Sciences, 2019
Background: Tuberculosis (TB) is one of the most significant health-care problems worldwide. The host’s genetics play an important role in the development of TB in humans.
Elena Yu. Bragina, Nadezhda P. Babushkina, Anna F. Garaeva, Alexey A. Rudko, Dmitry Yu. Tsitrikov, Densema E. Gomboeva, Maxim B. Freidin   +6 more
doaj   +1 more source

p22phox C242T Single-Nucleotide Polymorphism Inhibits Inflammatory Oxidative Damage to Endothelial Cells and Vessels. [PDF]

, 2016
BACKGROUND: The NADPH oxidase, by generating reactive oxygen species, is involved in the pathophysiology of many cardiovascular diseases and represents a therapeutic target for the development of novel drugs.
Brooks, G, Fan, LM, Ghazaly, MM, Howlin, B, Krönke, M, Li, J-M, Meijles, DN   +6 more
core   +1 more source

MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not. [PDF]

, 2008
The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients.
Hawinkels, LJAC, Hommes, DW, Kubben, FJGM, Lamers, CBHW, Langers, AMJ, Sier, CFM, van der Reijden, JJ, van Duijn, W, Verspaget, HW   +8 more
core   +2 more sources

Software for tag single nucleotide polymorphism selection

Human Genomics, 2005
This paper reviews the theoretical basis for single nucleotide polymorphism (SNP) tagging and considers the use of current software made freely available for this task. A distinction between haplotype block-based and non-block-based approaches yields two
Stram Daniel O
doaj   +1 more source

The C242T polymorphism of the NAD(P)H oxidase p22(phox) subunit is associated with an enhanced risk for cerebrovascular disease at a young age [PDF]

, 2008
Background and Purpose: Oxidative stress has been proposed as a major contributing factor for vascular disease, that acts independently from its participation in predisposing disorders such as diabetes and arterial hypertension.
Genius, Just, Grau, Armin J., Lichy, Christoph   +2 more
core   +1 more source