Results 11 to 20 of about 474,702 (256)
Detection of Single-Nucleotide Polymorphism
BioTechniques, 1998 Weikuan Gu +2 more
doaj +4 more sources
Electrophoretic Detection of Single-Nucleotide Polymorphisms [PDF]
BioTechniques, 2000 Single-nucleotide polymorphisms (SNPs) represent the most prevalent class of genetic markers available for linkage disequilibrium or cladistic analyses. PCR primers may be labeled with fluorescent dyes and used to rapidly and accurately differentiate among alleles that are defined by a single-nucleotide differences.
Deven R. See +3 more
openalex +5 more sources
Single-Nucleotide Polymorphisms in Soybean [PDF]
Genetics, 2003 Abstract Single-nucleotide polymorphisms (SNPs) provide an abundant source of DNA polymorphisms in a number of eukaryotic species. Information on the frequency, nature, and distribution of SNPs in plant genomes is limited. Thus, our objectives were (1) to determine SNP frequency in coding and noncoding soybean (Glycine max L.
Perry B. Cregan +12 more
openaire +3 more sources
Detection of Single Nucleotide Polymorphisms [PDF]
Current Issues in Molecular Biology, 2003 Single nucleotide polymorphism (SNP) detection technologies are used to scan for new polymorphisms and to determine the allele(s) of a known polymorphism in target sequences. SNP detection technologies have evolved from labor intensive, time consuming, and expensive processes to some of the most highly automated, efficient, and relatively inexpensive ...
Kwok, Pui-Yan, Chen, Xiangning
openaire +3 more sources
Genetic epidemiology of single-nucleotide polymorphisms [PDF]
Proceedings of the National Academy of Sciences, 1999 On the causal hypothesis, most genetic determinants of disease are single-nucleotide polymorphisms (SNPs) that are likely to be selected as markers for positional cloning. On the proximity hypothesis, most disease determinants will not be included among markers but may be detected through linkage disequilibrium with other SNPs.
Andrew Collins +2 more
openalex +5 more sources
MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not. [PDF]
, 2008 The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients.
Hawinkels, LJAC +8 more
core +2 more sources
Software for tag single nucleotide polymorphism selection
Human Genomics, 2005 This paper reviews the theoretical basis for single nucleotide polymorphism (SNP) tagging and considers the use of current software made freely available for this task. A distinction between haplotype block-based and non-block-based approaches yields two
Stram Daniel O
doaj +1 more source
The C242T polymorphism of the NAD(P)H oxidase p22(phox) subunit is associated with an enhanced risk for cerebrovascular disease at a young age [PDF]
, 2008 Background and Purpose: Oxidative stress has been proposed as a major contributing factor for vascular disease, that acts independently from its participation in predisposing disorders such as diabetes and arterial hypertension.
Genius, Just +2 more
core +1 more source
Revista Brasileira de Hematologia e Hemoterapia, 2015 Objective: To standardize the single nucleotide polymorphism array (SNPa) method in acute myeloid leukemia/myelodysplastic syndromes, and to identify the similarities and differ- ences between the results of this method and karyotyping.
Thiago Rodrigo de Noronha +2 more
doaj +1 more source
A novel DRD2 single-nucleotide polymorphism associated with schizophrenia predicts age of onset: HapMap tag-sincle-nucleotide polymorphism analysis [PDF]
, 2012 Background: Dopamine D2 receptor (DRD2) is thought to be critical in regulating the dopaminergic pathway in the brain which is known to be important in the aetiology of schizophrenia. It is therefore not surprising that most antipsychotic medication acts
Hughes, Ian +5 more
core +2 more sources