Results 311 to 320 of about 708,932 (401)

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu   +9 more
wiley   +1 more source

Aortic stenosis intricacies beyond the valve: A bidirectional Mendelian randomization study

open access: yesESC Heart Failure, EarlyView.
Abstract Aims Numerous observational studies have reported an association between calcific aortic valve stenosis (CAVS) and an increased risk of other cardiovascular diseases (CVDs). However, the potential causal association is uncertain. Methods and results A bidirectional Mendelian randomization (MR) analysis was performed to confirm the causal ...
Dihui Cai, Jianhui Liu
wiley   +1 more source

Circulating growth differentiation factor‐15 levels are associated with early echocardiographic signs of diastolic function impairment in the STANISLAS cohort: A 20‐year follow‐up study

open access: yesEuropean Journal of Heart Failure, EarlyView.
Summary of the study design and key findings. The (+) and (−) signs mean that the variable has a positive or a negative association with growth differentiation factor‐15 (GDF‐15) levels in the fully adjusted model (age, gender, current smoker, body mass index, total cholesterol, systolic blood pressure and N‐terminal pro‐B‐type natriuretic peptide ...
Luca Monzo   +11 more
wiley   +1 more source

Electrochemical sensing strategies for on‐site testing of pathogenic nucleic acids

open access: yesElectrochemical Science Advances, EarlyView.
Abstract Rapid and reliable on‐site pathogen testing is crucial for diagnosing and managing human health. Nucleic acids (NAs) containing genetic information are valuable target molecules for pathogen testing, and sensitive and rapid detection of NAs using electrochemical approaches has been intensively investigated.
Yusuke Kanno   +4 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons   +17 more
wiley   +1 more source

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