Results 81 to 90 of about 167 (165)
Discovering new hub genes of dilated cardiomyopathy
ESC Heart Failure, EarlyView.Abstract Aims Dilated cardiomyopathy (DCM) has a poor prognosis and exhibits a complex and diverse aetiology and genetic profile. The genes responsible for the pathogenesis of DCM have not been fully identified. The present study aimed to explore new hub genes of DCM by mining the human DCM databases and further by experimental validation.
Jun‐Yan Zhu +9 more
wiley +1 more source
ESC Heart Failure, EarlyView.Abstract Aims Atrial fibrillation (AF) is a frequent comorbidity in heart failure (HF). We analysed factors associated with new‐onset atrial fibrillation in patients with heart failure using linked real‐world UK data from primary and secondary care, along with findings from genome‐wide association studies. Methods and results Among 163 174 participants
Hiroyuki Yoshimura +6 more
wiley +1 more source
ESC Heart Failure, EarlyView.Abstract Aims Gut dysbiosis is proven to be involved in the pathogenesis and progression of heart failure (HF). Hindering the detrimental effects of gut‐heart axis is an emerging trend. Our goal is to investigate the causal relationship between gut microbiota and HF, with the aim of facilitating future exploration of microbiome‐targeted approaches to ...
Liyan Huang +8 more
wiley +1 more source
ESC Heart Failure, EarlyView.Abstract Aims Hypertrophic cardiomyopathy (HCM) is a rare genetic heart disease characterized by a limited patient population and scarce research and treatment resources. This study aimed to identify HCM‐associated proteins by integrating cardiac tissue data from the Gene Expression Omnibus (GEO) database with the latest protein quantitative trait ...
Bo Li, Xu Zhao, Yan Ding, Yi Zhang
wiley +1 more source
Multiomics insight into the role of glucagon‐like peptide‐1 receptor agonists in heart failure
ESC Heart Failure, EarlyView.Graphical abstract of the multiomics insight into the role of GLP1Ra in cardiovascular diseases and the underlying pathway. GLP1Ra, glucagon‐like peptide‐1 receptor agonist. Abstract Aims Cardiovascular diseases, such as atrial fibrillation, coronary artery disease, heart failure (HF) and ischaemic stroke, are leading causes of death globally and exert
Yuhang Tao +6 more
wiley +1 more source
Heritability and causality of QRS duration and chronic heart failure risk
ESC Heart Failure, EarlyView.Methodological framework used to investigate the heritability using linkage disequilibrium score regression (LDSC) and causal relationship between QRS duration (exposure) and chronic heart failure (outcome) using Mendelian randomization. QRS data were sourced from GWAS and exome‐wide association studies (EWAS), and chronic heart failure GWAS data were ...
Zequn Zheng, Xinhan Li, Yongfei Song
wiley +1 more source
European Journal of Heart Failure, EarlyView.Summary of the study design and key findings. The (+) and (−) signs mean that the variable has a positive or a negative association with growth differentiation factor‐15 (GDF‐15) levels in the fully adjusted model (age, gender, current smoker, body mass index, total cholesterol, systolic blood pressure and N‐terminal pro‐B‐type natriuretic peptide ...
Luca Monzo +11 more
wiley +1 more source
European Journal of Heart Failure, EarlyView.New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the ...
Alessandra Ghigo +22 more
wiley +1 more source
Electrochemical sensing strategies for on‐site testing of pathogenic nucleic acids
Electrochemical Science Advances, EarlyView.Abstract Rapid and reliable on‐site pathogen testing is crucial for diagnosing and managing human health. Nucleic acids (NAs) containing genetic information are valuable target molecules for pathogen testing, and sensitive and rapid detection of NAs using electrochemical approaches has been intensively investigated.
Yusuke Kanno +4 more
wiley +1 more source
Environmental and Molecular Mutagenesis, EarlyView.Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons +17 more
wiley +1 more source