Results 191 to 200 of about 10,468,963 (283)

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Homework Responsibility and Parent-Adolescent Communication: Maternal and Paternal Associations with Academic and Psychological Adjustment Among Chinese Adolescents. [PDF]

Behav Sci (Basel)
Zhang S, Mei Z, Yan S.
europepmc   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Factors associated with violent behavior among hospitalized adolescents with affective disorders: a two-center cross-sectional study. [PDF]

Front Psychiatry
Zhang Y, Cheng H, Li C, Yu H, Jiang W, Li G, Cai W.   +6 more
europepmc   +1 more source

Emergent Magnetism, Heavy Electrons, and Pressure‐Induced Reentrant Superconductivity in the Iron Substituted 4d Transition‐Metal Sulfides

Advanced Science, EarlyView.
This work illustrates that magnetic Fe substitution enables systematic modulation of physical properties of the putative unconventional superconductor Rh17S15. Iron doping uncovers delicate competition between weak ferromagnetism, spin‐glass states, heavy‐fermion signatures, and superconductivity.
Yalei Huang, Lu Xin, Na Zuo, Bin Li, Wei Zhou, Dhanarajagopal Alltrin, Boning Yu, Haiyang Yang, Bin Qian, Wen‐Chin Lin, Raman Sankar, Michael Smidman, Xiangzhuo Xing, Chunqiang Xu, Xiaobing Liu, Jianhui Dai, Dong Qian, Shiyan Li, Xiaofeng Xu   +18 more
wiley   +1 more source

Combining Ability Analysis and Identification of Testers for Biomass Yield and Forage Quality Traits in Guineagrass (<i>Megathyrsus maximus</i>). [PDF]

Plants (Basel)
Hernandez LM, Acuña CA, Jauregui RN.
europepmc   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Telomere length of both parents contributes to heritable POT1 cancer-predisposition syndrome. [PDF]

Nat Commun
Martin A, Lu R, Blake A, Nichols KE, Sanchez SE, Artandi SE, Savage SA, Sharma R, Hockemeyer D.   +8 more
europepmc   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source