Results 131 to 140 of about 26,554 (252)

Src-dependent tyrosine-phosphorylation of NM2A has a protective role against bacterial pore-forming toxins. [PDF]

PLoS Pathog
Brito C, Mesquita FS, Pereira JM, Osório DS, Billington N, Lima RR, Vale-Costa S, Sellers JR, Cabanes D, Carvalho AX, Sousa S.   +10 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Future Pneumococcal Vaccines: Shifting from Capsular Polysaccharides to Protein-Based Immunogens. [PDF]

Vaccines (Basel)
Zheng R, Shu J, Xie X, Zhao C, Zhang S, Zhang X, Xu J.   +6 more
europepmc   +1 more source

075323 - EPDM Membrane Roofing [PDF]

, 2013
Weatherbee, Stephanie
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

<i>In vitro</i> and <i>in vivo</i> evaluation of humanized monoclonal antibodies targeting pneumolysin. [PDF]

Microbiol Spectr
Song L, Hu H, Huang J, Li H, Zhang Y, Ma N, Song Z.   +6 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Double-diaphragm forming of highly aligned short-fibre preforms for complex composite parts. [PDF]

Int J Mater Form
Gordon T, Yavuz O, Zhang B, Sun X, Hamerton I, Longana ML, Hallett SR, Belnoue JP, Kim BC.   +8 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Modeling of Preforming Process for Unidirectional Prepreg Composites Using Simplified Linear Friction Model and Fiber-Tracking Method. [PDF]

Polymers (Basel)
Li Z, Song Q, Liu J, Liu W, Chen P, Yue G.   +5 more
europepmc   +1 more source