Results 61 to 70 of about 5,077 (210)

Simulation Analysis of Air Distribution in the Public Area of Single-Span Arch-Shaped Underground Station under the Centralized Air Return Mode

Chengshi guidao jiaotong yanjiu
［Objective］ Due to the relatively high floor height and the special structural form of arched top plates, the single-span arch-shaped underground station poses higher requirements for decoration.
FENG Rao, LUO Yanping, LI Bijia, HU Zilin   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Investigation of the response characteristics of urban waterlogging to model rainfall patterns taking into account the spatial distribution of rainfall

Shuili Shuiyun Gongcheng Xuebao
Urban waterlogging is primarily caused by short-duration rainstorms, and the rainfall pattern significantly influences the impact of waterlogging disasters.
LIANG Xin, HOU Jingming, CHEN Guangzhao, LI Donglai, PAN Xinxin, LÜ Jiahao, MA Yue, JI Guoqiang   +7 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Research on Single Photon Laser Communication Detection and Receiving Technology Based on Baseband Pulse Sampling

IEEE Photonics Journal
To realize the efficient transmission of deep space communication, single photon detection technology is used to overcome the signal attenuation and noise problems in long-distance transmission.
Yapei Sheng, Min Zhang, Jiao Dong, Ziyi Gao, Li Xu, Peng Lin, Keyan Dong, Xiaonan Yu   +7 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Robust Blue‐Green Urban Flood Risk Management Optimised With a Genetic Algorithm for Multiple Rainstorm Return Periods

Journal of Flood Risk Management
Flood risk managers seek to optimise Blue‐Green Infrastructure (BGI) designs to maximise return on investment. Current systems often use optimisation algorithms and detailed flood models to maximise benefit–cost ratios for single rainstorm return periods.
Asid Ur Rehman, Vassilis Glenis, Elizabeth Lewis, Chris Kilsby, Claire Walsh   +4 more
doaj   +1 more source

The Impact of Housing Prices on Chinese Migrants’ Return Intention: A Moderation Analysis of Public Services

Buildings
Housing prices are a topic of significant social concern, and public services are a crucial factor influencing migrants’ return intentions. Based on the China Labour Force Dynamics Survey and China Real Estate Index database from 2012 to 2018, this study
Yuxin Liao, Jinhui Song, Wen Zuo, Rui Luo, Xuefang Zhuang, Rong Wu   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Are fear memories erasable? –reconsolidation of learned fear with fear relevant and fear-irrelevant stimuli

Frontiers in Behavioral Neuroscience, 2012
Recent advances in the field of fear learning have demonstrated that a single reminder exposure prior to extinction training can prevent the return of extinguished fear by disrupting the process of reconsolidation. These findings have however proven hard
Armita eGolkar, Martin eBellander, Andreas eOlsson, Arne eÖhman   +3 more
doaj   +1 more source