Results 71 to 80 of about 591,186 (303)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Research on Single Photon Laser Communication Detection and Receiving Technology Based on Baseband Pulse Sampling

IEEE Photonics Journal
To realize the efficient transmission of deep space communication, single photon detection technology is used to overcome the signal attenuation and noise problems in long-distance transmission.
Yapei Sheng, Min Zhang, Jiao Dong, Ziyi Gao, Li Xu, Peng Lin, Keyan Dong, Xiaonan Yu   +7 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The Impact of Housing Prices on Chinese Migrants’ Return Intention: A Moderation Analysis of Public Services

Buildings
Housing prices are a topic of significant social concern, and public services are a crucial factor influencing migrants’ return intentions. Based on the China Labour Force Dynamics Survey and China Real Estate Index database from 2012 to 2018, this study
Yuxin Liao, Jinhui Song, Wen Zuo, Rui Luo, Xuefang Zhuang, Rong Wu   +5 more
doaj   +1 more source

Are fear memories erasable? –reconsolidation of learned fear with fear relevant and fear-irrelevant stimuli

Frontiers in Behavioral Neuroscience, 2012
Recent advances in the field of fear learning have demonstrated that a single reminder exposure prior to extinction training can prevent the return of extinguished fear by disrupting the process of reconsolidation. These findings have however proven hard
Armita eGolkar, Martin eBellander, Andreas eOlsson, Arne eÖhman   +3 more
doaj   +1 more source

Is There a Risk and Return Relation? [PDF]

, 2020
Traditional finance theory posits that the relation between the risk and return of stocks is positive. Furthermore, investment practice is often based on the central contention that high (low) beta stocks earn higher (lower) returns.
McMillan, David G., McMillan, Fiona, McMillan, Fiona J., McMillan, David, Fifield, Suzanne, Fifield, Suzanne G. M.; id_orcid   +5 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Robust Blue‐Green Urban Flood Risk Management Optimised With a Genetic Algorithm for Multiple Rainstorm Return Periods

Journal of Flood Risk Management
Flood risk managers seek to optimise Blue‐Green Infrastructure (BGI) designs to maximise return on investment. Current systems often use optimisation algorithms and detailed flood models to maximise benefit–cost ratios for single rainstorm return periods.
Asid Ur Rehman, Vassilis Glenis, Elizabeth Lewis, Chris Kilsby, Claire Walsh   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source