Results 111 to 120 of about 15,461,022 (332)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Blacks’ Diminished Return of Education Attainment on Subjective Health; Mediating Effect of Income

open access: yesBrain Science, 2018
Background: Minorities’ Diminished Return (MDR) can be defined as smaller health gains from socioeconomic status (SES) indicators, such as education attainment among ethnic minorities compared to the majority group.
S. Assari
semanticscholar   +1 more source

Product Return Handling [PDF]

open access: yes
In this article we focus on product return handling and warehousingissues. In some businesses return rates can be well over 20% andreturns can be especially costly when not handled properly.
Koster, M.B.M. de, Brito, M.P. de
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Gendered reacculturation and marriage negotiation among single Chinese female returnees

open access: yesBMC Public Health
Background Returning home after international study can involve complex readjustment, especially when personal life plans, family expectations, workplace experiences, and broader social norms do not fully align.
Ruining Jin, Boya Wu, Jie Wei, Xiao Wang
doaj   +1 more source

Low rates of patients meeting return to sport criteria 9 months after anterior cruciate ligament reconstruction: a prospective longitudinal study

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, 2018
PurposeThe purpose of the current prospective study was to assess the changes over time in patients tested at 6 months and 9 months after anterior cruciate ligament reconstruction (ACLR) with a return to sport (RTS) test battery. It was hypothesized that
W. Welling   +5 more
semanticscholar   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Functional outcome in patients following cartilage regeneration outcome at minimum follow-up of 12 months

open access: yesOrthopaedic Journal of Sports Medicine, 2020
Introduction: Several studies have focused on the return to play rate after ACL reconstruction. Whereas most studies just report the rate as a result, only few studies evaluate specific parameters and tests to further investigate the conditions of when ...
Christian Liefke   +3 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

THE SINGLE INDEX MARKET MODEL IN AGRICULTURE [PDF]

open access: yes
This study illustrates the differences in empirical results due to data measurements and estimating procedures when applying the single index market model in agriculture.
Tambe, A.M.   +3 more
core  

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