Results 71 to 80 of about 561,200 (260)

Simulation Analysis of Air Distribution in the Public Area of Single-Span Arch-Shaped Underground Station under the Centralized Air Return Mode

Chengshi guidao jiaotong yanjiu
［Objective］ Due to the relatively high floor height and the special structural form of arched top plates, the single-span arch-shaped underground station poses higher requirements for decoration.
FENG Rao, LUO Yanping, LI Bijia, HU Zilin   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Research on Single Photon Laser Communication Detection and Receiving Technology Based on Baseband Pulse Sampling

IEEE Photonics Journal
To realize the efficient transmission of deep space communication, single photon detection technology is used to overcome the signal attenuation and noise problems in long-distance transmission.
Yapei Sheng, Min Zhang, Jiao Dong, Ziyi Gao, Li Xu, Peng Lin, Keyan Dong, Xiaonan Yu   +7 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The Impact of Housing Prices on Chinese Migrants’ Return Intention: A Moderation Analysis of Public Services

Buildings
Housing prices are a topic of significant social concern, and public services are a crucial factor influencing migrants’ return intentions. Based on the China Labour Force Dynamics Survey and China Real Estate Index database from 2012 to 2018, this study
Yuxin Liao, Jinhui Song, Wen Zuo, Rui Luo, Xuefang Zhuang, Rong Wu   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Robust Blue‐Green Urban Flood Risk Management Optimised With a Genetic Algorithm for Multiple Rainstorm Return Periods

Journal of Flood Risk Management
Flood risk managers seek to optimise Blue‐Green Infrastructure (BGI) designs to maximise return on investment. Current systems often use optimisation algorithms and detailed flood models to maximise benefit–cost ratios for single rainstorm return periods.
Asid Ur Rehman, Vassilis Glenis, Elizabeth Lewis, Chris Kilsby, Claire Walsh   +4 more
doaj   +1 more source

Are fear memories erasable? –reconsolidation of learned fear with fear relevant and fear-irrelevant stimuli

Frontiers in Behavioral Neuroscience, 2012
Recent advances in the field of fear learning have demonstrated that a single reminder exposure prior to extinction training can prevent the return of extinguished fear by disrupting the process of reconsolidation. These findings have however proven hard
Armita eGolkar, Martin eBellander, Andreas eOlsson, Arne eÖhman   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source