Results 71 to 80 of about 1,563 (195)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

An Entropic Estimator for Linear Inverse Problems

Entropy, 2012
In this paper we examine an Information-Theoretic method for solving noisy linear inverse estimation<em> </em>problems which encompasses under a single framework a whole class of estimation methods. Under this framework, the prior information
Amos Golan, Henryk Gzyl
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Parallelization of the NASA Goddard Cumulus Ensemble Model for Massively Parallel Computing

Terrestrial, Atmospheric and Oceanic Sciences, 2007
Massively parallel computing, using a message passing interface (MPI), has been implemented into a three-dimensional version of the Goddard Cumulus Ensemble (GCE) model.
Hann-Ming Henry Juang, Wei-Kuo Tao, Xiping Zeng, Chung-Lin Shie, Stephen Lang, Joanne Simpson   +5 more
doaj   +1 more source

Single Trial Decoding of Belief Decision Making from EEG and fMRI Data Using ICA Features

Frontiers in Human Neuroscience, 2013
The complex task of assessing the veracity of a statement is thought to activate uniquely distributed brain regions based on whether a subject believes or disbelieves a given assertion.
Pamela eDouglas, Edward eLau, Ariana eAnderson, Wesley eKerr, Austin eHead, Margalit Aliza Wollner, Daniel eMoyer, Michael eDurnhofer, Wei eLi, Jen eBramen, Mark S Cohen   +10 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Finite Hypergraph Families with Rich Extremal Turán Constructions via Mixing Patterns

Forum of Mathematics, Sigma
We prove that, for any finite set of minimal r-graph patterns, there is a finite family $\mathcal F$ of forbidden r-graphs such that the extremal Turán constructions for $\mathcal F$ are precisely the maximum r-graphs obtainable from mixing
Xizhi Liu, Oleg Pikhurko
doaj   +1 more source