Results 51 to 60 of about 2,160,503 (336)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Definable Singularity [PDF]

Transactions of the American Mathematical Society, 1991
The main result of this paper is a characterization of singular cardinals in terms of the core model, assuming that there is no model of ∃ κ o ( κ ) = κ + + \exists \kappa \,o(\kappa )= {\kappa ^{ +
openaire   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Por uma nova concepção de universal

Revista Latinoamericana de Psicopatologia Fundamental, 2009
A civilização ocidental baseia-se na concepção de um universal que faça corpo único de todos os elementos, o que só se mostrou possível por meio da produção de restos inassimiláveis, e a consequente tentativa de eliminá-los por meio de perseguições ou ...
Oswaldo França Neto
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Procedimentos intervencionistas para o manejo da dor no câncer

Einstein (São Paulo), 2012
OBJETIVO: Descrever tipos de procedimentos (seu uso racional e alguns de seus benefícios) realizados em pacientes com câncer tratados em um hospital privado de São Paulo.
Fabiola Peixoto Minson, Fabrício Dias Assis, Thais Kfouri Vanetti, Jamir Sardá Junior, Wanessa Pereira Mateus, Auro Del Giglio   +5 more
doaj  

Singular random matrix decompositions: distributions. [PDF]

, 2002
Assuming that Y has a singular matrix variate elliptically contoured distribution with respect to the Hausdorff measure, the distributions of several matrices associated to QR, modified QR, SV and Polar decompositions of matrix Y are determined, for ...
Díaz García, José A., González Farías, Graciela   +1 more
core   +2 more sources

SMOOTH ORDER SINGULARITIES [PDF]

Journal of Algebra and Its Applications, 2003
In [4] it was shown that the center of Cayley–Hamilton smooth orders is smooth whenever the central dimension is at most 2 and that there may be singularities in higher dimensions. In this paper, we give methods to classify central singularities of smooth orders up to smooth equivalence in arbitrary dimension and show that these methods are strong ...
Bocklandt, Raf, Le Bruyn, Lieven, van de Weyer, Geert   +2 more
openaire   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source