Results 51 to 60 of about 173,827 (269)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Singular truth-conditions without singular propositions [PDF]

open access: yesSynthese, 2017
In this paper I argue that propositionalism (the doctrine that the contents of thoughts and utterances are propositions to be evaluated with respect to possible worlds) is what generates a tension between referentialism and harmony (the traditional idea that cognitive values can be fully explained by means of truth-conditional contents). Harmony can be
openaire   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Singular LQ Problem for Irregular Singular Systems

open access: yesJournal of Applied Mathematics, 2014
This paper is concerned with the singular LQ problem for irregular singular systems with persistent disturbances. The full information feedback control method is employed to achieve the optimal control. By restricted system equivalence transformation, the system state is decomposed into free state and restricted state and the input is decomposed into ...
Qingxiang Fang   +2 more
openaire   +3 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

On the Links of Simple Singularities, Simple Elliptic Singularities and Cusp Singularities

open access: yesDemonstratio Mathematica, 2015
Abstract This is a survey article about the study of the links of some complex hypersurface singularities in ℂ3 . We study the links of simple singularities, simple elliptic singularities and cusp singularities, and the canonical contact structures on them. It is known that each singularity link is diffeomorphic to a compact quotient of
openaire   +3 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

PrimerEvalPy: a tool for in-silico evaluation of primers for targeting the microbiome

open access: yesBMC Bioinformatics
Background The selection of primer pairs in sequencing-based research can greatly influence the results, highlighting the need for a tool capable of analysing their performance in-silico prior to the sequencing process. We therefore propose PrimerEvalPy,
Lara Vázquez-González   +5 more
doaj   +1 more source

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