Results 41 to 50 of about 345,470 (293)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A Study of Singular Similarity Solutions to Laplace’s Equation with Dirichlet Boundary Conditions

AppliedMath
The infinite series solution to the boundary-value problems of Laplace’s equation with discontinuous Dirichlet boundary conditions was found by using the basic method of separation of variables.
Chao-Kang Feng, Jyh-Haw Tang
doaj   +1 more source

Boundary contributions to specific heat and susceptibility in the spin-1/2 XXZ chain

, 2004
Exact low-temperature asymptotic behavior of boundary contribution to specific heat and susceptibility in the one-dimensional spin-1/2 XXZ model with exchange anisotropy 1/2 < \Delta \le 1 is analytically obtained using the Abelian bosonization method ...
A. Furusaki, A. Furusaki, A. Furusaki, C.L. Kane, D.C. Cabra, F.H.L. Essler, H. Asakawa, H. Frahm, K.A. Matveev, N.M. Bogoliubov, P. Fröjdh, P. Fröjdh, P.A. de Sa, S. Eggert, S. Fujimoto, S. Fujimoto, S. Lukyanov, S. Lukyanov, S. Lukyanov, S. Qin, S.R. White, S.R. White, T. Hikihara, T. Hikihara, T. Hikihara, T. Hikihara   +25 more
core   +1 more source

Meshless Singular Boundary Method for Nonlinear Sine-Gordon Equation [PDF]

Mathematical Problems in Engineering, 2018
A meshless method based on the singular boundary method is developed for the numerical solution of the time-dependent nonlinear sine-Gordon equation with Neumann boundary condition. In this method, by using a time discrete scheme to approximate the time derivatives, the time-dependent nonlinear problem is transformed into a sequence of time-independent
openaire   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Multi-Scale-Matching neural networks for thin plate bending problem

Theoretical and Applied Mechanics Letters
Physics-informed neural networks are a useful machine learning method for solving differential equations, but encounter challenges in effectively learning thin boundary layers within singular perturbation problems.
Lei Zhang, Guowei He
doaj   +1 more source

A Galerkin method of O(h2) for singular boundary value problems

International Journal of Mathematics and Mathematical Sciences, 2002
We describe a Galerkin method with special basis functions for a class of singular two-point boundary value problems. The convergence is shown which is of O(h2) for a certain subclass of the problems.
G. K. Beg, M. A. El-Gebeily
doaj   +1 more source

The solution to Wheeler-DeWitt is eight

, 1994
We describe a new geometrical solution to the Wheeler-DeWitt equation in two dimensional quantum gravity. The solution is the amplitude of a surface whose boundary consists of two tangent loops.
Adi, Adi, David, DeWitt, Distler, E. Adi, Elitzur, Hartle, Moore, S. Solomon, Tutte   +10 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Structural Shape Optimization Based on Multi-Patch Weakly Singular IGABEM and Particle Swarm Optimization Algorithm in Two-Dimensional Elastostatics

Mathematics
In this paper, a multi-patch weakly singular isogeometric boundary element method (WSIGABEM) for two-dimensional elastostatics is proposed. Since the method is based on the weakly singular boundary integral equation, quadrature techniques, dedicated to ...
Zhenyu Chen, Longtao Xie
doaj   +1 more source