Results 61 to 70 of about 672,012 (336)

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Finite-part singular integral approximations in Hilbert spaces

International Journal of Mathematics and Mathematical Sciences, 2004
Some new approximation methods are proposed for the numerical evaluation of the finite-part singular integral equations defined on Hilbert spaces when their singularity consists of a homeomorphism of the integration interval, which is a unit circle, on ...
E. G. Ladopoulos, G. Tsamasphyros, V. A. Zisis   +2 more
doaj   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Singular integrals with angular integrability

, 2016
In this note we prove a class of sharp inequalities for singular integral operators in weighted Lebesgue spaces with angular integrability.Comment: 5 pages - updated ...
Cacciafesta, Federico, Lucà, Renato
core   +1 more source

Singular Volterra integral equations

Applied Mathematics Letters, 2000
The authors study the existence of a nonnegative solution to the Volterra integral equation \[ y(t) = h(t)+ \int_0^t k(t,s)f(s,y(s)) ds,\quad t\in [0,T], \] where the nonlinearity \(f(t,y)\) may be singular at \(y=0\). The assumptions used are such that they easily get a result on the existence of a solution of the singular initial value problem \(y ...
Agarwal, R.P., O'Regan, D.
openaire   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Multilinear strongly singular integral operators on non-homogeneous metric measure spaces

Journal of Inequalities and Applications, 2022
Let ( X , d , μ ) $(X,d,\mu )$ be a non-homogeneous metric measure space satisfying the geometrically and upper doubling measure conditions. In this paper, the boundedness in Lebesgue spaces for multilinear strongly singular integral operators on non ...
Hailian Wang, Rulong Xie
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Elliptic perturbations for Hammerstein equations with singular nonlinear term

Electronic Journal of Differential Equations, 2006
We consider a singular elliptic perturbation of a Hammerstein integral equation with singular nonlinear term at the origin. The compactness of the solutions to the perturbed problem and, hence, the existence of a positive solution for the ...
Giuseppe Maria Coclite, Mario Michele Coclite   +1 more
doaj