Results 71 to 80 of about 672,012 (336)
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Наука. Инновации. Технологии, 2022 The work out lines a method of constructing an approximate solution of a differential equation of the second order with input data obtained in the experiment (empirical functions).
Igor Eduardovich Naats +2 more
doaj
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Quantitative Weighted Estimates of the Lq-Type Rough Singular Integral Operator and Its Commutator
MathematicsLet Ω be a homogeneous function of degree zero on Rn, n≥2, integrable and having mean value zero on the unit sphere Sn−1, and let TΩ be the homogeneous convolution singular integral operator with kernel Ω(x)|x|n.
Shuo Wang, Peize Lv, Xiangxing Tao
doaj +1 more source
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
FEBS Open Bio, EarlyView.Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah +8 more
wiley +1 more source
MathematicsIn this paper, for a mixed elliptic-hyperbolic type equation with various degeneration orders and singular coefficients, theorems of uniqueness and existence of the solution to the problem with a missing Tricomi condition on boundary characteristic and ...
Assel Makulbay +3 more
doaj +1 more source
Физика волновых процессов и радиотехнические системы, 2019 The singular integral equation of a thin tubular vibrator is considered. This paper analyzed the dependence of the eigenvalues of the integral operator of the singular integral equation on the frequency and geometric dimensions of the vibrator with the ...
D.P. Tabakov, A.G. Mayorov
doaj +1 more source
A Direct Method for Solving Singular Integrals in Three-Dimensional Time-Domain Boundary Element Method for Elastodynamics [PDF]
, 2022 Xiaofei Qin +3 more
openalex +1 more source