Results 261 to 270 of about 166,500 (329)

Elucidating reaction dynamics in a model of human brain energy metabolism. [PDF]

open access: yesPLoS Comput Biol
Patsatzis DG   +4 more
europepmc   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

open access: yesAdvanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann   +26 more
wiley   +1 more source

The quark jet function for k T -like variables in NNLO QCD. [PDF]

open access: yesEur Phys J C Part Fields
Buonocore L   +4 more
europepmc   +1 more source

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