Results 141 to 150 of about 8,505 (264)

Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model

Advanced Science, EarlyView.
A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen, Yang Zhao, Boqiang Hu, Wuke Wang, Minfang Song, Annabeth Xinyu Zhao, Xiangyang Li, Gefei Wang, Yanfen Wang, Weiyan Zheng, Xinpeng Zhang, Xia Lin, Yanbin Yin, Xingxu Huang, Jinfang Zheng, Tingbo Liang   +15 more
wiley   +1 more source

Local-nonlocal assisted multifunctional photonic crystals. [PDF]

Light Sci Appl
Lv W, Qin H, Shi X, Shi F, Mu X, Zhou Z, Qin J, Li B, Qiu CW, Song Q.   +9 more
europepmc   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Analytical investigation of soliton dynamics in the Fokas-Lenells equation with generalized self-phase modulation and nonlinear dispersion. [PDF]

Sci Rep
Rehman HU, Khushi K, Yildirim Y, Allahyani SA, Gusu DM.   +4 more
europepmc   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Analysis strategies for time-resolved X-ray solution scattering at high repetition rate XFEL sources. [PDF]

J Synchrotron Radiat
Haubro ML, Zederkof DB, Khakhulin D, Yousef H, Jiang Y, Macias IJB, Kluyver T, Lima F, Biednov M, Milne C, Uemura Y, Zalden P, Wang H, Dohn AO, Mitterer K, Markmann V, Ohlson O, Wachter-Lehn MT, Lenzen P, Jensen BK, Høholdt A, van Driel TB, Nimmrich A, Selenius E, Levi G, Møller KB, Nielsen MM, Haldrup K.   +27 more
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Soliton solutions with bifurcation, sensitivity, chaotic and stability analysis of the (2+1)-dimensional Zoomeron equation using generalized Riccati equation mapping method. [PDF]

Sci Rep
Zainab A, Saad KM, Abbas M, Hamanah WM, Yousaf MZ, Birhanu A.   +5 more
europepmc   +1 more source

Singular perturbations [PDF]

Bulletin of the American Mathematical Society, 1962
openaire   +2 more sources

Solid Harmonic Wavelet Bispectrum for Image Analysis

Advanced Science, EarlyView.
The Solid Harmonic Wavelet Bispectrum (SHWB), a rotation‐ and translation‐invariant descriptor that captures higher‐order (phase) correlations in signals, is introduced. Combining wavelet scattering, bispectral analysis, and group theory, SHWB achieves interpretable, data‐efficient representations and demonstrates competitive performance across texture,
Alex Brown, Mathilda Avirett‐Mackenzie, Carolin Villforth, Georgios Exarchakis   +3 more
wiley   +1 more source