Results 171 to 180 of about 73,706 (315)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Tate-Hochschild cohomology, the singularity category and applications

, 2020
Following work of Buchweitz, one defines Tate-Hochschild cohomology of an algebra A to be the Yoneda algebra of the identity bimodule in the singularity category of bimodules.
Keller, Bernhard
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Singularity Compose: Orchestration for Singularity Instances [PDF]

Journal of Open Source Software, 2019
openaire   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

sylabs/singularity: SingularityCE 4.1.2

<p>SingularityCE 4.1.1 is a patch release in the 4.1 series, including various bug fixes.</p> <h3>Bug Fixes</h3> <ul> <li>Set OCI runtime-spec annotations that are required by the documented image-spec conversion ...
Dave Trudgian, David Godlove, Felix Abecassis, Carl Madison, Amanda Duffy, Mike Frisch, Gregory M. Kurtzer, Brian P Bockelman, Daniele Tamino, Justin Cook, Jacob Chappell, cclerget, Geoffroy Vallee, DrDaveD, Michael Bauer, Jason Stover, Adam Hughes, Tru Huynh, Mike Gray, Sasha Yakovtseva, Marcelo Magallon, Yannick Cote, Ian Kaneshiro, Yaroslav Halchenko, Satrajit Ghosh, Vanessasaurus, Carlos Eduardo Arango Gutierrez, VP   +27 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

A simplified proof of a cosmological singularity theorem. [PDF]

Gen Relativ Gravit
Galloway GJ, Ling E.
europepmc   +1 more source

On Singular and non Singular Rings [PDF]

AL-Rafidain Journal of Computer Sciences and Mathematics, 2006
Nazar Shuker, Husam Mohammad, Shaimaa Ahmad   +2 more
openaire   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source