Results 241 to 250 of about 581,282 (341)

A Novel Single-Loop Mechanism for Neck Rehabilitation. [PDF]

Biomimetics (Basel)
Di Gregorio R.
europepmc   +1 more source

EXACT BOUNDARY BEHAVIOR OF SOLUTIONS TO SINGULAR NONLINEAR DIRICHLET PROBLEMS

, 2014
Bo Li, Zhijun Zhang, Li, B (reprint author), Lanzhou Univ, Sch Math & Stat, Lanzhou 730000, Peoples R China.   +2 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Pipeasm: a tool for automated large chromosome-scale genome assembly and evaluation. [PDF]

Bioinform Adv
Marques Silva B, Trindade FJ, Costa Canesin LE, Souza G, Aleixo A, Nunes G, Moreira-Oliveira RR.   +6 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

MeTAline: enabling reproducible and scalable metagenomic analyses. [PDF]

NAR Genom Bioinform
Khannous-Lleiffe O, Fuentes-Palacios D, Májer D, Gabaldón T.   +3 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The biomechanical effect of different spring extension assist mechanisms in mechanical 4-bar polycentric prosthetic knees for unilateral above/through-knee amputees. [PDF]

Prosthet Orthot Int
Toderita D, Favier CD, Milandri GS, Vardakastani V, Henson DP, Bull AM.   +5 more
europepmc   +1 more source

Radiology report generation from a singular perspective using transformers with Knowledge Distillation

Asad Khan, Mashood Mohammad Mohsan, Muhammad Usman Akram, Taimur Hassan, Sajid Gul Khawaja, Adil Qayyum   +5 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source