Results 271 to 280 of about 581,282 (341)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Singularity transformation through single-pass phase modulation of light. [PDF]

Sci Rep
Laxminarayan, Allam SR, Omatsu T, Kumar P.   +3 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Hawking's Singularity Theorem for Lipschitz Lorentzian Metrics. [PDF]

Commun Math Phys
Calisti M, Graf M, Hafemann E, Kunzinger M, Steinbauer R.   +4 more
europepmc   +1 more source

Direct and Inverse Estimates For Combinations of Bernstein Polynomials with Endpoint Singularities

, 2015
Wen-ming Lu
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

NGPINT V3: a containerized orchestration Python software for discovery of next-generation protein-protein interactions. [PDF]

Bioinformatics
Smith SD, Velásquez-Zapata V, Wise RP.
europepmc   +1 more source

APLICAÇÃO DO PROJETO TERAPÊUTICO SINGULAR (PTS) COMO MELHORA NA QUALIDADE DE VIDA DOS CUIDADORES DE PACIENTE ACAMADO

, 2016
Flávio Pereira dos Santos, Janaina Benatti de Almeida, Michelle Mayumi Taia Koyama   +2 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Energy evolution law and catastrophic failure prediction of Luohe formation sandstone during rupture process experienced one freeze-thaw cycle. [PDF]

PLoS One
Zhang L, Ren J, Yun M, Zhang Y, Liu B, Zhang K.   +5 more
europepmc   +1 more source