Results 151 to 160 of about 72,352 (232)

Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction

Scientific Reports, 2017
Adenylyl cyclase type 9 (AC9) is found tightly associated with the scaffolding protein Yotiao and the IKs ion channel in heart. But apart from potential IKs regulation, physiological roles for AC9 are unknown.
Yong Li, Tanya A. Baldwin, Yan Wang, Janani Subramaniam, Anibal Garza Carbajal, Cameron S. Brand, Shane R. Cunha, Carmen W. Dessauer   +7 more
doaj   +1 more source

Artificial Cardiac Conduction System: Simulating Heart Function for Advanced Computational Problem Solving [PDF]

arXiv
This work proposes a novel bio-inspired metaheuristic called Artificial Cardiac Conduction System (ACCS) inspired by the human cardiac conduction system. The ACCS algorithm imitates the functional behaviour of the human heart that generates and sends signals to the heart muscle, initiating it to contract.
arxiv  

Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction [PDF]

Aims: In patients with heart failure (HF), concomitant sinus node dysfunction (SND) is an important predictor of mortality, yet its molecular underpinnings are poorly understood.
Achter, Jonathan, Al-Othman, Sami, Banner, Jytte, Boyett, Mark R., D'Souza, Alicia, Hansen, Finn B., Hu, Wei, Jensen, Thomas H.L., Kahnert, Konstantin, Lundby, Alicia, Maurya, Svetlana, Mills, Robert W., Olesen, Morten S., Olsen, Kristine Boisen, Smith, Matthew, Soattin, Luca, Sorrentino, Andrea, Tikhomirov, Roman, van de Vegte, Yordi J., van der Harst, Pim, Wilson, Claire, Zhang, Henggui, Zi, Min   +22 more
core   +1 more source

Genetically Modified Porcine Mesenchymal Stem Cells by Lentiviral Tbx18 Create a Biological Pacemaker

Stem Cells International, 2019
Background. Tbx18 is a vital transcription factor involved in embryonic sinoatrial node (SAN) formation process but is gradually vanished after birth.
Yannan Hu, Ning Li, Liang Liu, Hao Zhang, Xiang Xue, Xin Shao, Yu Zhang, Xilong Lang   +7 more
doaj   +1 more source

Experimental investigation of the flow downstream of a dysfunctional bileaflet mechanical aortic valve [PDF]

arXiv, 2019
Mechanical heart valve replacement is the preferred alternative in younger patients with severe symptomatic aortic valve disease. However, thrombus and pannus formations are common complications associated with bileaflet mechanical heart valves. This leads to risks of valve leaflet dysfunction, a life threatening event.
arxiv  

Oral Abstracts for the 17th Asia Pacific Heart Rhythm Society (APHRS) Scientific Sessions

Journal of Arrhythmia, Volume 41, Issue 2, April 2025.
wiley   +1 more source

Standard Poster Abstracts for the 17th Asia Pacific Heart Rhythm Society (APHRS) Scientific Sessions

Journal of Arrhythmia, Volume 41, Issue 2, April 2025.
wiley   +1 more source

Dual network structure of the AV node [PDF]

arXiv
Biological systems, particularly the brain, are frequently analyzed as networks, conveying mechanistic insights into their function and pathophysiology. This is the first study of a functional network of cardiac tissue. We use calcium imaging to obtain two functional networks in a subsidiary but essential pacemaker of the heart, the atrioventricular ...
arxiv  

Cardiac Consequences of Selective Adrenergic Cell Ablation in Mice [PDF]

, 2016
Phenylethanolamine-N-methyltransferase (Pnmt), is the enzyme that catalyzes the conversion of noradrenaline to adrenaline. It has been found in the embryonic heart and in certain adult heart cells, including intrinsic cardiac adrenergic cells ...
Tumuluri, Lahari
core   +1 more source

Dissecting The Tissue-Specific Contributions To Seizures, Cardiorespiratory Dysfunction, And Sudden Death In The Kv1.1 Mouse Model Of Epilepsy Using Conditional Knockout Approaches [PDF]

Sudden unexpected death in epilepsy (SUDEP), the primary cause of mortality in epilepsy, remains poorly understood. Studies suggest seizures may trigger dangerous signals affecting the heart and lungs leading to collapse and death.
Paulhus, Kelsey
core   +1 more source