Results 161 to 170 of about 44,700 (293)

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Oral TYK2 Inhibitor D‐2570 in Healthy Subjects: A First‐in‐Human Phase I Study

open access: yesClinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT D‐2570 selectively binds to the pseudokinase domain of tyrosine kinase 2, which mediates the downstream cytokine signaling pathways involved in immune regulation. The safety, tolerability, pharmacokinetics, and pharmacodynamics of D‐2570 were evaluated in a randomized, double‐blind, placebo‐controlled phase I study conducted in healthy Chinese
Meng Wang   +4 more
wiley   +1 more source

Amustaline/glutathione pathogen‐reduced red cell hemoglobin utilization in complex cardiac surgery: A post hoc analysis of the phase 3 ReCePI trial

open access: yesTransfusion, Volume 66, Issue 1, Page 72-83, January 2026.
Abstract Background The ReCePI randomized, controlled trial compared amustaline/glutathione pathogen‐reduced (PR) and conventional red blood cell (RBC) transfusions in cardiac surgery. Study design and methods We performed a post‐hoc analysis of hemoglobin (Hb) utilization and safety outcomes.
Ian J. Welsby   +11 more
wiley   +1 more source

Novel Magnetic Resonance Imaging Findings of Bilaterally Symmetrical Lesions in a Dog With Concomitant Granulomatous Meningoencephalitis and Necrotizing Encephalitis

open access: yesVeterinary Radiology &Ultrasound, Volume 67, Issue 1, January 2026.
ABSTRACT A 3‐year‐old, female neutered Bichon Frise was presented with a 2‐day history of behavioral changes and ataxia. The neurological examination was consistent with diffuse forebrain involvement, with left lateralization. An MRI study identified bilaterally symmetrical T2W/T2 fluid‐attenuated inversion recovery (T2‐FLAIR) hyperintense, T1W ...
Tessa Victoria Procter   +5 more
wiley   +1 more source

Physiology of nitrogen: A life or death matter

open access: yesExperimental Physiology, Volume 111, Issue 1, Page 270-282, 1 January 2026.
Abstract With each breath, four out of every five molecules we inspire are nitrogen (N2), since this gas constitutes ∼80% of the atmospheric air that surrounds us. Despite its abundance and unlike molecular oxygen, N2 has traditionally held less appeal among physiologists given its lack of reactivity and corresponding inability to support combustion or
Damian M. Bailey   +2 more
wiley   +1 more source

Management of Ablation‐Refractory Atrial Fibrillation During Pregnancy

open access: yesCase Reports in Medicine, Volume 2026, Issue 1, 2026.
Development of new atrial fibrillation (AF) is uncommon in pregnancy with an incidence of 0.03%. The occurrence of drug‐refractory AF during pregnancy in individuals with structurally normal hearts is even rarer, and there are no reports of ablation‐refractory AF during pregnancy in the literature.
Faris Abu Za’nouneh   +5 more
wiley   +1 more source

Corticosteroid-induced sinus bradycardia in a young boy with adrenal insufficiency and sepsis

open access: diamond, 2021
Emine Ayça Cimbek   +4 more
openalex   +1 more source

Myelodysplastic Syndrome With Complex Chromosomal Karyotype Abnormalities Complicated by Multiple Intestinal Perforations: A Case Report and Literature Review

open access: yesCase Reports in Gastrointestinal Medicine, Volume 2026, Issue 1, 2026.
Background Myelodysplastic syndromes (MDSs) are clonal hematopoietic disorders often associated with cytogenetic abnormalities, among which trisomy 8 is one of the most common abnormalities. Trisomy 8 is linked to autoimmune manifestations, including Behçet‐like disease, especially with gastrointestinal involvement.
Zhan-Yue Niu   +6 more
wiley   +1 more source

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