Results 41 to 50 of about 42,114 (261)

Brugada Syndrome: New Implications for Heterozygous Carriers of the Pathogenic SCN5A c.689T>C(p.Ile230Thr) Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Pathogenic variants in the SCN5A gene and its subunits have been identified in individuals with Brugada Syndrome. One such SCN5A variant, c.689T>C(p.Ile230Thr), was previously reported as disease‐causing only in homozygous individuals, with heterozygous carriers being unaffected.
Shayla Shojaat, Benjamin Hale, Taylor Warner   +2 more
wiley   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Carotid sinus hypersensitivity: Entity warrants a caution in the critical care unit

Journal of the Scientific Society, 2016
Carotid sinus hypersensitivity (CSH) syndrome is an entity caused by an overreaction of the carotid sinus baroreceptors to stimulation. Three subtypes of CSH syndrome are recognized according to the response to carotid sinus massage (CSM): Predominantly ...
Sugata Dasgupta, Soumi Das, Arunima Chaudhuri   +2 more
doaj   +1 more source

Long‐Term Outcomes of Reduced Intensity Conditioning Hematopoietic Stem Cell Transplantation for Systemic Sclerosis Patients with Impaired Cardiac Function

Arthritis &Rheumatology, Accepted Article.
Objective High intensity conditioning autologous hematopoietic stem cell transplantation (AHSCT) is standard of care for patients with advanced SSc. The role of reduced intensity conditioning (RIC) prior to AHSCT in this population remains unclear. We conducted this study to determine the long‐term outcomes of RIC AHSCT in SSc patients with cardiac ...
Yonatan Lean, Carrie Richardson, Anthony Esposito, Katy Bedjeti, George E. Georges   +4 more
wiley   +1 more source

A case of successful catheter ablation of blocked atrial bigeminy and bradycardia with the recovery of normal sinus rhythm and myocardial reverse remodeling

Clinical Case Reports, 2022
A 69‐year‐old man presented bradycardia with a constant blocked atrial bigeminy and heart failure. Successful catheter ablation of blocked atrial bigeminy with bradycardia resulted in myocardial reverse remodeling and restoration of the normal sinus ...
Tomomi Sugiyama, Yoshiaki Mizutani, Satoshi Yanagisawa, Masaaki Kanashiro, Yasuya Inden, Toyoaki Murohara   +5 more
doaj   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Excessive Ostial Stent Protrusion: Evaluation of Management Strategies and Clinical Outcomes of the Side Flap Technique

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Backgrounds Accurate stent positioning in aorto‐ostial lesions remains challenging due to complex three‐dimensional anatomy, lack of optimal fluoroscopic projections, and high rates of geographic miss. Stent overhang impairs guide catheter re‐engagement and complicates future revascularization.
Gregor Leibundgut, M. Bilal Iqbal, Claudiu Ungureanu, Anastasios Barmpas, Jasper Boeddinghaus, Teodor Buliga, Gabor G. Toth, Alexandru Achim   +7 more
wiley   +1 more source

Beta-Blocker-Related Atrioventricular Conduction Disorders—A Single Tertiary Referral Center Experience

Medicina, 2022
Background and Objectives: Drug-related bradyarrhythmia is a well-documented major adverse event among beta-blocker users and a potential cause for hospitalization or additional interventions.
Dragoș Traian Marius Marcu, Cristina Andreea Adam, Dan-Mihai Dorobanțu, Delia Lidia Șalaru, Radu Andy Sascău, Mircea Ovanez Balasanian, Liviu Macovei, Cătălina Arsenescu-Georgescu, Cristian Stătescu   +8 more
doaj   +1 more source

Shining new light on mammalian diving physiology using wearable near-infrared spectroscopy [PDF]

, 2019
Investigation of marine mammal dive-by-dive blood distribution and oxygenation has been limited by a lack of non-invasive technology for use in freely diving animals.
Balfour, Steve, Bennett, Kimberley A., Bivins, Matt, Bronkhorst, Mathijs, Colier, Willy, Hall, Ailsa J., McKnight, J. Chris, Milne, Ryan, Moss, Simon E. W., Russell, Debbie J. F., Thompson, Dave   +10 more
core   +4 more sources

Transthyretin amyloid cardiomyopathy: Literature review and red‐flag symptom clusters for each cardiology specialty

ESC Heart Failure, Volume 12, Issue 2, Page 955-967, April 2025.
Abstract Wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is a progressive and infiltrative cardiac disorder that may cause fatal consequences if left untreated. The estimated survival time from diagnosis is approximately 3–6 years. Because of the non‐specificity of initial symptom manifestation and insufficient awareness among treating ...
Yasuhiro Izumiya, Toru Kubo, Jin Endo, Seiji Takashio, Masatoshi Minamisawa, Jun Hamada, Tomonori Ishii, Hajime Abe, Hiroaki Konishi, Kenichi Tsujita   +9 more
wiley   +1 more source