Results 301 to 310 of about 620,324 (385)

Acute intermittent hypoxia in neonatal rodent central nervous system facilitates respiratory frequency through the recruitment of hypothalamic areas

open access: yesExperimental Physiology, EarlyView.
Abstract Moderate and acute intermittent hypoxia (IH) facilitates respiration in adults, mostly by recruiting peripheral chemo‐/baroreceptors. As central chemoreceptors are widely expressed in immature brains, we hypothesized that IH modulates respiration at birth through a purely neurogenic mechanism involving the hypothalamus.
Rosamaria Apicella   +2 more
wiley   +1 more source

Dual-chamber vs. single-chamber pacemaker in patients in sinus rhythm with an atrioventricular block: a nationwide cohort study. [PDF]

open access: yesEuropace
Bodin A   +8 more
europepmc   +1 more source

Integrative cardiovascular dose–response to graded lower‐body negative pressure

open access: yesExperimental Physiology, EarlyView.
ABSTRACT Lower‐body negative pressure (LBNP) has been posited as a potential spaceflight countermeasure to counteract the physiological deconditioning related to fluid shifts in microgravity. However, open questions remain regarding the magnitude of LBNP that should be applied.
Richard S. Whittle   +5 more
wiley   +1 more source

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker   +2 more
wiley   +1 more source

Cellular and molecular cross‐talk in atrial fibrillation: The role of non‐cardiomyocytes in creating an arrhythmogenic substrate

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Illustration of cellular and molecular cross‐talk in atrial fibrillation. Left: a schematic of cardiac tissue showing cardiomyocytes, fibroblasts, adipocytes, inflammatory cells and the coagulation system. Right: direct and indirect cross‐talk between different cell types, with the impact of direct cross‐talk on action potential (
Zhenyu Dong   +2 more
wiley   +1 more source

Prospective in silico trials identify combined SK and K2P channel block as an effective strategy for atrial fibrillation cardioversion

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend In silico trials were conducted in 654 virtual patients with atrial fibrillation (AF) to assess the cardioversion efficacy of three pharmacological treatments: single SK and K2P channel block and combined SK+K2P channel inhibition. Left: representative virtual AF patient with the atria inside the torso.
Albert Dasí   +4 more
wiley   +1 more source

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