Results 41 to 50 of about 201,732 (280)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

Inappropriate sinus tachycardia presented during pregnancy (clinical case)

Acta Biomedica Scientifica
Inappropriate sinus tachycardia (IST) is a sinus tachycardia unexplained by visible physiological and secondary causes with a resting heart rate of more than 100 beats per minute. The true prevalence of IST is unknown.
E. S. Eniseeva, K. V. Protasov, O. V. Fedorishina, T. P. Vlasyuk, N. A. Khramtsova   +4 more
doaj   +1 more source

Safety and pharmacokinetics of mosliciguat, a new, inhaled soluble guanylate cyclase activator, in healthy adult subjects

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mosliciguat (BAY 1237592), the first soluble guanylate cyclase (sGC) activator in a dry powder inhaler (DPI), could potentially treat pulmonary hypertension with a more targeted delivery than systemic sGC stimulators. We report safety and tolerability of mosliciguat in healthy men.
Johannes Nagelschmitz, Soundos Saleh, Sandra Ligges, Melanie Seidel‐Greven, Eva Becker‐Pelster, Sylvia M. Nikkho, Stefanie Boxnick, Wolfgang Timmer   +7 more
wiley   +1 more source

Our experience in the diagnosis and treatment of postural orthostatic tachycardia syndrome, vasovagal syncope, and inappropriate sinus tachycardia in children

Türk Kardiyoloji Derneği Arşivi, 2017
Objectives: The aim of this study was to share our experience in the diagnosis and treatment of patients who presented at our clinic with syncope, pre-syncope, dizziness, and palpitations.
Sezen Ugan Atik, Reyhan Dedeoglu, Aida Koka, Funda Oztunc   +3 more
doaj   +1 more source

Idiopathic Fascicular Ventricular Tachycardia [PDF]

, 2004
Idiopathic fascicular ventricular tachycardia is an important cardiac arrhythmia with specific electrocardiographic features and therapeutic options. It is characterized by relatively narrow QRS complex and right bundle branch block pattern. The QRS axis
Anoop K. Gupta, Johnson Francis, Francis, Johnson, N, Sudhayakumar, Venugopal K, Sudhayakumar N, K, Venugopal, SA, Khadar, Gupta, Anoop K, Khadar SA   +9 more
core  

Refractory paroxysmal sinus tachycardia: Management by subtotal right atrial exclusion [PDF]

, 1984
A 27 year old woman presented with recurrent episodes of disabling paroxysmal sinus tachycardia (150 to 180 beats/min) in the absence of identifiable organic disease. Tachycardia was resistant to all drug therapy.
Gulamhusein, Sajad S., Yee, Raymond, Guiraudon, Gerard M., Gardner, Martin J., Klein, George J.   +4 more
core   +1 more source

Exploring the early observations of parents supporting their children with school attendance problems (SAPs): A co‐produced study

British Educational Research Journal, EarlyView.
Abstract School Attendance Problems (SAPs) represent a significant challenge requiring early identification and intervention. Current service provision often does not recognise early indicators that parents observe, creating gaps between when initial concerns are raised and formal support is provided.
Tereza Aidonopoulou‐Read, Michelle Pyer, Beth Bodycote, Jackie Campbell, Kirsteen Pyer   +4 more
wiley   +1 more source

Radiofrequency catheter ablation of inappropriate sinus tachycardia guided by activation mapping [PDF]

, 2000
OBJECTIVE The purpose of this study was to evaluate the value of activation mapping for radiofrequency modification of the sinus node and the long-term success rate of the procedure in a series of patients with inappropriate sinus tachycardia. BACKGROUND:
Flemming, M, K.Ching Man, Pelosi, Frank, Knight, Bradley, Gregory F Michaud, Matthew Flemming, S.Adam Strickberger, Fred Morady, Pelosi, F, Man, K.Ching, Hung-Fat Tse, Frank Pelosi, Man, KC, Knight, B, Michaud, GF, Morady, F, Tse, HF, Flemming, Matthew, Bradley Knight, Tse, Hung-Fat, Strickberger, SA, Michaud, Gregory F, Strickberger, S.Adam, Morady, Fred   +23 more
core   +1 more source

A Large Retrospective Study to Evaluate Utility of Zephyr Covered Stent in Transcatheter Closure of Sinus Venosus Defects

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Transcatheter closure (TCC) of sinus venosus defects (SVD) using balloon‐expandable covered stents is an emerging alternative to surgery. ZephyrCS (Sahajanand Laser Technologies, Gandhinagar, India) is available in long lengths to suit SVD closure.
Pramod Sagar, Puthiyedath Thejaswi, Kothandam Sivakumar, Praveen Ashok Kumar   +3 more
wiley   +1 more source