Results 121 to 130 of about 111,116 (318)

Immunodeficiency and Surgical Outcomes in Chronic Rhinosinusitis

open access: yes
The Laryngoscope, EarlyView.
Jaynelle Gao, Corey Karp, Kevin Hur
wiley   +1 more source

Current Insights Into Individualized Diagnosis and Treatment of Allergic Rhinitis Based on Phenotype and Endotype

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa characterized by allergen sensitization and the involvement of multiple inflammatory mediators. Currently, the treatment of AR mainly includes symptomatic relief, anti‐inflammatory therapy, and nerve desensitization. However, these treatments have limitations in fully
Yue Gu   +7 more
wiley   +1 more source

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou   +4 more
wiley   +1 more source

Effect of host‐protein test (TRAIL/IP‐10/CRP) on antibiotic prescription and emergency department or urgent care center return visits: The JUNO pilot randomized controlled trial

open access: yesAcademic Emergency Medicine, EarlyView.
Abstract Objectives Determining etiology for adults with symptoms of lower respiratory tract infection (LRTI) is challenging. MeMed BV (MMBV), an FDA‐cleared blood test, computationally integrates the levels of three host proteins to differentiate bacterial and viral infections.
Adam J. Singer   +14 more
wiley   +1 more source

Acute Respiratory Tract Infections and How to Treat Them [PDF]

open access: yes, 2019
Acute respiratory tract infections (ARTIs) are one of the most common clinical encounters in primary care settings and they often lead to antibiotic prescriptions. However, more than 90% of ARTIs are caused by viral syndromes.
Seth, Shivani
core   +1 more source

Epithelial Lining Fluid Cystatin SN is a Noninvasive Biomarker for Predicting Type 2 Chronic Rhinosinusitis

open access: yesAllergy, EarlyView.
Cystatin SN is highly expressed in the epithelial lining fluid (ELF) of patients with type 2 (T2) chronic rhinosinusitis (CRS). ELF cystatin SN expression correlates with nasal T2/eosinophilic inflammation and impaired olfactory function. ELF cystatin SN is a non‐invasive biomarker for predicting T2 CRS with superior accuracy.
Seojin Moon   +7 more
wiley   +1 more source

Efficacy of ASA Therapy After Desensitization on CRSwNP Patients With Asthma and N‐ERD—A Randomized Clinical Trial

open access: yesAllergy, EarlyView.
This randomized double‐blind clinical trial investigated the impact of aspirin therapy after desensitization in patients with CRSwNP, asthma, and N‐ERD. Various clinical outcomes were assessed, including health‐related quality of life (with the SNOT‐22 questionnaire) and the severity of nasal polyposis (with the NPS).
Alma Helevä   +9 more
wiley   +1 more source

Rituximab in combination with high-dose methylprednisolone for the treatment of chronic lymphocytic leukemia. [PDF]

open access: yes, 2009
We observed that high-dose methylprednisolone (HDMP) and rituximab was well tolerated and had promising activity when used in combination to treat patients with fludarabine-refractory chronic lymphocytic leukemia (CLL).
Bole, J   +6 more
core  

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