How Safe Are Oxygen–Ozone Therapy Procedures for Spine Disc Herniation? The SIOOT Protocols for Treating Spine Disorders [PDF]
Journal of ImagingOxygen–ozone (O2–O3) therapy is widely used for treating lumbar disc herniation. However, controversy remains regarding the safest and most effective route of administration. While intradiscal injection is purported to show clinical efficacy, it has also
Marianno Franzini +12 more
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SIOOT® Adjunct Oxygen-Ozone Therapy Against Multidrug-Resistant Bacteria: A Pilot Study of 257 Cases [PDF]
AntibioticsBackground/Objectives: Antimicrobial resistance (AMR) represents one of the greatest challenges to modern medicine, particularly in chronic infections sustained by multidrug-resistant (MDR) pathogens and biofilm formation.
Marianno Franzini +3 more
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Ozone adjunct treatment in facing multidrug‐resistant bacteria? [PDF]
Clinical Case Reports, 2023 Clinical Case Reports, Volume 11, Issue 10, October 2023.
Salvatore Chirumbolo +2 more
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The Oxygen–Ozone Adjunct Medical Treatment According to the Protocols from the Italian Scientific Society of Oxygen–Ozone Therapy: How Ozone Applications in the Blood Can Influence Clinical Therapy Success via the Modulation of Cell Biology and Immunity [PDF]
Biology, 2023 Background. Ozone is an allotrope of oxygen whose use in medicine has rapidly grown in recent years. Ozonated blood allows for the use of ozone in a safe modality, as plasma and blood cells are endowed with an antioxidant system able to quench ozone’s ...
Salvatore Chirumbolo +12 more
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The Role of Ozone as an Nrf2-Keap1-ARE Activator in the Anti-Microbial Activity and Immunity Modulation of Infected Wounds [PDF]
Antioxidants, 2023 Ozone is an allotrope of oxygen, widely known to exert an anti-oxidant potential. The ability of low, controlled and standardized doses of ozone in the ozone adjunct treatment of bacterial infections, which occur in wounds, is engaging clinical research ...
Marianno Franzini +5 more
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The Mito-Hormetic Mechanisms of Ozone in the Clearance of SARS-CoV2 and in the COVID-19 Therapy [PDF]
Biomedicines, 2022 An increasing body of evidence in the literature is reporting the feasibility of using medical ozone as a possible alternative and adjuvant treatment for COVID-19 patients, significantly reducing hospitalization time, pro-inflammatory indicators, and ...
Salvatore Chirumbolo +7 more
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The Translational Medicine Regarding Ozone in Saline Solutions. Comment on Armeli et al. Ozone Saline Solution Polarizes Microglial Cells Towards an Anti-Inflammatory Phenotype. Molecules 2025, 30, 3932 [PDF]
MoleculesThis commentary critically evaluates the translational relevance of a recent study investigating the effects of ozonated saline solution (O3SS) on microglial and endothelial cell models. While the original research proposes potential antioxidant and anti-
Marianno Franzini +2 more
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Use of oxygen-ozone therapy to improve the effectiveness of antibiotic treatment on infected arthroplasty: protocol for a superiority, open-label, multicentre, randomised, parallel trial [PDF]
BMJ OpenIntroduction Surgical site infections still remain a major public health challenge and have become an increasing universal risk, especially for the implantation of orthopaedic devices.Unfortunately, the discovery and increasingly widespread use ...
Walter Ricciardi +7 more
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Commentary: Ozone therapy as a novel complementary therapeutic approach in refractory idiopathic granulomatous mastitis [PDF]
Frontiers in Medicine, 2023 Salvatore Chirumbolo +4 more
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The biological activity of medical ozone in the hormetic range and the role of full expertise professionals [PDF]
Frontiers in Public Health, 2022 Marianno Franzini +8 more
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