Results 81 to 90 of about 570,641 (287)

Resolvin D5 Inhibits CXCL8 Expression in Colonic Epithelial Cells Through Activating GPR101 to Impede Neutrophil Recruitment and Consequently Alleviate Ulcerative Colitis

Advanced Science, EarlyView.
RvD5 effectively alleviates UC by inhibiting STAT1 signaling to reduce CXCL8 expression in colonic epithelial cells via activation of GPR101, which subsequently decreases the infiltration of neutrophils in the colonic mucosal epithelium. Epimedin A1, a natural allosteric inhibitor of 5‐LOX, demonstrates potential as a therapeutic agent for UC by ...
Pengxiang Guo, Yilei Guo, Yanrong Zhu, Ke Yan, Yulai Fang, Jiafeng Zhang, Yue He, Zhifeng Wei, Yufeng Xia, Yue Dai   +9 more
wiley   +1 more source

Large vessel occlusion mediated fluid attenuated inversion recovery signal intensity ratio is associated with stroke within 4.5 h

Frontiers in Neurology
IntroductionThe primary objective was to investigate the value of the fluid attenuated inversion recovery (FLAIR) signal intensity ratio (SIR) in identifying stroke within 4.5 h.
Yajing Wang, Qianqian Mao, Liang Jiang, Mingyang Peng, Yu-Chen Chen, Hong Zhang, Liwei Wang, Xindao Yin   +7 more
doaj   +1 more source

MODEL STOKASTIK SUSCEPTIBLE INFECTED RECOVERED (SIR) [PDF]

, 2013
Felin Yunita. 2013. MODEL STOKASTIK SUSCEPTIBLE INFECTED RECOVERED (SIR). Fakultas Matematika dan Ilmu Pengetahuan Alam. Universitas Sebelas Maret. Model susceptible infected recovered (SIR) menjelaskan penyebaran penyakit dari individu susceptible ...
Yunita, Felin
core  

Model reference control for SIRS models

Discrete & Continuous Dynamical Systems - A, 2009
The purpose of this paper is to introduce the model reference control method (MRC) in system biology. We review the main framework of MRC based on neural networks and some research issues. The model reference control for some model biological systems plant is considered.
Shui-Nee Chow, Yongfeng Li
openaire   +1 more source

Lipid‐Facilitated Opening of the ADAM10 Sheddase Revealed by Enhanced Sampling Simulations

Advanced Science, EarlyView.
Phosphatidylserine acts as a lipid trigger to enhance activation of the sheddase ADAM10. By integrating fluorescence spectroscopy assays with enhanced sampling molecular dynamics simulations, this study shows that phosphatidylserine promotes ADAM10 catalytic activity along with expansion of its extracellular domains, enhancing accessibility to scaffold
Adrien Schahl, Nandan Haloi, Marta Carroni, Shengpan Zhang, Quentin James Sattentau, Erdinc Sezgin, Lucie Delemotte, Rebecca J. Howard   +7 more
wiley   +1 more source

Epidemic Thresholds with External Agents

, 2013
We study the effect of external infection sources on phase transitions in epidemic processes. In particular, we consider an epidemic spreading on a network via the SIS/SIR dynamics, which in addition is aided by external agents - sources unconstrained by
Banerjee, Siddhartha, Chatterjee, Avhishek, Shakkottai, Sanjay   +2 more
core   +1 more source

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

Advanced Science, EarlyView.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang, Maodong Leng, Chenchen Sun, Jingyu Cao, Linfei Li, Yangyang Jia, Yongshuai Han, Yuchun Liu, Yaodong Zhang, Chenglong Zhang, Yingli Men, Ningyuan Liu, Yibing Cheng, Yixia Zhang, Ya Li, Zhenlong Li, Lidan Cui, Xiangzhan Zhu   +17 more
wiley   +1 more source

A stochastic numerical computing heuristic of SIR nonlinear model based on dengue fever

Results in Physics, 2020
The purpose of the current work is to solve the SIR nonlinear model based on dengue fever using a stochastic numerical computing scheme together with the artificial neural networks (ANNs) optimized by a well-known global genetic algorithm (GA) and local ...
Muhammad Umar, Zulqurnain Sabir, Muhammad Asif Zahoor Raja, Yolanda Guerrero Sánchez   +3 more
doaj   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Network-based analysis of stochastic SIR epidemic models with random and proportionate mixing

, 2007
In this paper, we outline the theory of epidemic percolation networks and their use in the analysis of stochastic SIR epidemic models on undirected contact networks.
Kenah, Eben, Robins, James M.
core   +6 more sources