Results 111 to 120 of about 60,209 (283)

Mortality in Tuberous Sclerosis Complex in the United Kingdom, 2016–2022

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Tuberous sclerosis complex (TSC) is a genetic condition caused by mutations in either TSC1 or TSC2 genes, affecting around two million people globally. This study aims to examine causes of death in TSC and explore factors contributing to mortality in people with TSC in the United Kingdom in recent years following updated management ...
Callum Richard Thomas Kidson, Ne‐Ron Loh, Yasir Ahmed Syed   +2 more
wiley   +1 more source

The paradox of cancer genes in non-malignant conditions: implications for precision medicine. [PDF]

, 2020
Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures.
Adashek, Jacob J, Kato, Shumei, Kurzrock, Razelle, Lippman, Scott M   +3 more
core  

A Surgical Perspective on Targeted Therapy of Hepatocellular Carcinoma. [PDF]

, 2015
Hepatocellular carcinoma (HCC), the second leading cause of cancer deaths worldwide, is difficult to treat and highly lethal. Since HCC is predominantly diagnosed in patients with cirrhosis, treatment planning must consider both the severity of liver ...
Busuttil, Ronald W, Faltermeier, Claire, Zarrinpar, Ali   +2 more
core   +2 more sources

Exploring the Influence of Oral and Gut Microbiota on Ulcerative Mucositis: A Pilot Cohort Study

Oral Diseases, EarlyView.
ABSTRACT Aim Comparing oral and gut microbiome profiles between patients with and without ulcerative mucositis during allogeneic stem cell transplantation (aSCT). Materials and Methods Specimens from oral mucosa, saliva, and stool were collected pre‐(T0) and post‐ (T0 +28d ± 14d) aSCT (T1).
Valentin Bartha, Sébastien Boutin, Dorothée L. Schüßler, Anna Felten, Shila Fazeli, Florentina Kosely, Thomas Luft, Diana Wolff, Cornelia Frese, Kyrill Schoilew   +9 more
wiley   +1 more source

Coadministration of fluconazole to boost subtherapeutic sirolimus concentrations: A case report

Pharmacology Research & Perspectives
Individual sirolimus whole blood concentrations are highly variable, critically influenced by the concomitant use of cytochrome P450 (CYP) 3A inducers or inhibitors, and also modulated by food.
Camilo Scherkl, Andreas D. Meid, Sven E. Cuntz, Laura Classen, Johanna Weiss, David Czock, Walter E. Haefeli   +6 more
doaj   +1 more source

A randomized phase II study to evaluate tacrolimus in combination with sirolimus or methotrexate after allogeneic hematopoietic cell transplantation

Haematologica, 2012
Background There is evidence suggesting that sirolimus, in combination with tacrolimus, is active in the prevention of graft-versus-host disease. Sirolimus-based immune suppression may suppress alloreactive T cells, while sparing the survival and ...
Joseph Pidala, Jongphil Kim, Heather Jim, Mohamed A. Kharfan-Dabaja, Taiga Nishihori, Hugo F. Fernandez, Marcie Tomblyn, Lia Perez, Janelle Perkins, Mian Xu, William E. Janssen, Anandaraman Veerapathran, Brian C. Betts, Frederick L. Locke, Ernesto Ayala, Teresa Field, Leonel Ochoa, Melissa Alsina, Claudio Anasetti   +18 more
doaj   +1 more source

The role of acquired host immunity in periodontal diseases

Periodontology 2000, EarlyView.
Abstract The aim of this narrative review is to relate the contribution of European researchers to the complex topic of the host immune system in periodontal disease, focusing on acquired immunity. Other chapters in this volume will address the genetics and autoantibody responses and other forms of immunity to periodontal disease.
Denis F. Kinane, David F. Lappin, Shauna Culshaw   +2 more
wiley   +1 more source

Invasive Aspergillosis in Mice Immunosuppressed with Cyclosporin A, Tacrolimus (FK506), or Sirolimus (Rapamycin) [PDF]

, 1997
Kevin P. High, Ronald G. Washburn
openalex   +1 more source

Preclinical evaluation of injectable sirolimus formulated with polymeric nanoparticle for cancer therapy [PDF]

Nanoparticles are useful delivery vehicles for promising drug candidates that face obstacles for clinical applicability. Sirolimus, an inhibitor of mammalian target of rapamycin has gained attention for targeted anticancer therapy, but its clinical ...
Choi, Eun Kyung, Chung, Hye Kyung, Jeong, Seong-Yun, Ju, Eun Jin, Jung, Joohee, Kang, Hye-Won, Lee, Jin Seong, Lee, Jung Shin, Lee, Sa-Won, Park, Heon Joo, Seo, Min-Hyo, Song, Si Yeol, Woo, Ha Na   +12 more
core   +3 more sources

Relationship Between Body Weight and Leukopenia in Non‐Kidney Solid Organ Transplant Recipients With Normal Renal Function Who Are Receiving Valganciclovir for CMV Prophylaxis

Transplant Infectious Disease, EarlyView.
Liver, lung, or heart transplant recipients who receive valganciclovir prophylactically are at risk for leukopenia. Our data suggest that in solid organ transplant (SOT) recipients with normal renal function, receiving a fixed dose of VGC resulted in a significant, inverse relationship between body weight and the development of leukopenia.
Sara Haddad, Kevin Dee, Augusto Dulanto Chiang, Fionna Feller, Tan Ding, Gregory D. Ayers, Marissa Potts, Richard W. LaRue   +7 more
wiley   +1 more source