Results 131 to 140 of about 60,209 (283)

Unbiased Drug Target Prediction Reveals Sensitivity to Ferroptosis Inducers, HDAC and RTK Inhibitors in Melanoma Subtypes

International Journal of Dermatology, Volume 64, Issue 5, Page 870-881, May 2025.
Drug target prediction algorithms based on proteogenomic profiling. Abstract Background The utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment of malignant melanoma (MM). However, resistance to targeted and immune‐checkpoint‐based therapies still poses a significant problem.
Indira Pla, Botond L. Szabolcs, Petra Nikolett Péter, Zsuzsanna Ujfaludi, Yonghyo Kim, Peter Horvatovich, Aniel Sanchez, Krzysztof Pawlowski, Elisabet Wieslander, Magdalena Kuras, Jimmy Rodriguez Murillo, Jéssica Guedes, Dorottya M.P. Pál, Anna A. Ascsillán, Lazaro Hiram Betancourt, István Balázs Németh, Jeovanis Gil, Natália Pinto de Almeida, Beáta Szeitz, Leticia Szadai, Viktória Doma, Nicole Woldmar, Áron Bartha, Zoltan Pahi, Tibor Pankotai, Balázs Győrffy, A. Marcell Szasz, Gilberto Domont, Fábio Nogueira, Ho Jeong Kwon, Roger Appelqvist, Sarolta Kárpáti, David Fenyö, Johan Malm, György Marko‐Varga, Lajos V. Kemény   +35 more
wiley   +1 more source

Sirolimus based immunosuppression is associated with need for early repeat therapeutic ERCP in liver transplant patients with anastomotic biliary stricture

Annals of Hepatology, 2013
Introduction. Sirolimus has inhibitory effects on epithelial healing and cholangiocyte regeneration. In liver transplantation (LT) patients, these effects may be greatest at the biliary anastomosis.
James H. Tabibian, M.D., Mohit Girotra, Hsin-Chieh Yeh, Dorry L. Segev, Murat T. Gulsen, Guldane Cengiz-Seval, Vikesh K. Singh, Andrew M. Cameron, Ahmet Gurakar   +8 more
doaj  

Native BK Viral Nephropathy After Pediatric Heart Transplantation Treated With Bilateral Native Nephrectomy and Living Donor Kidney Transplantation: A Case Report

Pediatric Transplantation, Volume 29, Issue 3, May 2025.
ABSTRACT Background BK Polyoma virus (BKV) can lead to significant renal complications in immunocompromised individuals. While commonly observed in kidney transplant recipients, its occurrence in non‐renal solid organ transplant (NRSOT) recipients remains rare.
Kann Rachel, Meshkin Dana, Crane Andrew, Salgado Claudia, Xu Qingyong, Ganoza Armando   +5 more
wiley   +1 more source

Acquired Genotype‐Positive Long QT Syndrome After Pediatric Heart Transplantation

Pediatric Transplantation, Volume 29, Issue 3, May 2025.
ABSTRACT Background Congenital long QT syndrome (LQTS) is rare but significant, as it carries a risk for ventricular arrhythmias and sudden cardiac death. Its diagnosis can be made clinically by serial ECGs, ambulatory ECG monitoring, and exercise stress testing; however, genetic testing is confirmatory in the majority of cases.
Nicholas V. Barresi, Jessica Sebastian, Gaurav Arora, Brian Feingold   +3 more
wiley   +1 more source

Validation of an Assay for Routine Monitoring of Sirolimus Using HPLC with Mass Spectrometric Detection [PDF]

, 2000
David W. Holt, Terry Lee, K Jones, A. E. Johnston   +3 more
openalex   +1 more source

Safety and tolerability of sirolimus treatment in patients with autosomal dominant polycystic kidney disease [PDF]

, 2017
Background. We initiated a randomized controlled clinical trial to assess the effect of sirolimus on disease progression in patients affected by autosomal dominant polycystic kidney disease (ADPKD).
Kistler, Andreas D., Krauer, Fabienne, Pavik, Ivana, Poster, Diane, Raina, Shagun, Regeniter, Axel, Rentsch, Katharina, Senn, Oliver, Serra, Andreas L., Weishaupt, Dominik, Wüthrich, Rudolf P.   +10 more
core  

Functional Complete Revascularization as Determined by an Optimized Scoring System After Revascularization: A Post Hoc Analysis from Multi‐Center PANDA III Trial

Advanced Science, Volume 12, Issue 14, April 10, 2025.
The modified residual functional SYNTAX score (m‐rFSS) algorithm was updated for 2 clinical scenarios: 1) lesions with suboptimal functional results, and 2) angiographic diameter stenosis <50% but functionally significant stenoses, which were not scored by classic rFSS or rSS.
Rui Zhang, Shaoyu Wu, Qianqian Liu, Changdong Guan, Hao‐Yu Wang, Sheng Yuan, Lihua Xie, Yunfei Huang, Zheng Qiao, Weida Liu, Rui Fu, Lei Feng, Chenggang Zhu, Lei Song, Dong Yin, Kefei Dou   +15 more
wiley   +1 more source

Vascular Healing After Biodegradable Polymer Sirolimus‐Eluting Versus Durable Polymer Everolimus‐Eluting Stents in Chronic Total Occlusions

Catheterization and Cardiovascular Interventions, Volume 105, Issue 5, Page 1124-1133, April 1, 2025.
ABSTRACT Background Biodegradable polymer stents may reduce the risk of neoatherosclerosis and stent thrombosis. Limited data is available for biodegradable polymer sirolimus‐eluting stent (BP‐SES) and durable polymer drug‐eluting stents (DP‐EES) in chronic total occlusions (CTO).
Geng Wang, Yi Li, Wen Lu, Yawei Xu, Xi Su, Shaoliang Chen, Yang Li, Yaling Han, the TARGET CTO OCT substudy Investigators   +8 more
wiley   +1 more source

An unusual cause of cancer mimicry following liver transplantation

Annals of Hepatology, 2012
Sirolimus is an approved anti-rejection agent following liver or kidney transplantation that works through inhibition of the mammalian target of rapamycin (mTOR). As sirolimus functions through a pathway independent of calcineurin inhibition, it may have
Karim Qumosani, Natasha Chandok
doaj  

Leaky Artemis Deficiency and EBV‐Related Lymphoproliferative Disease: A Novel Case and Review of the Literature

eJHaem, Volume 6, Issue 2, April 2025.
ABSTRACT Introduction Artemis (DCLRE1C) deficiency causes radiosensitive severe combined immunodeficiency (SCID), although hypomorphic cases can manifest later‐onset immunodeficiency, autoimmunity, or lymphoproliferation. We report a 45‐year‐old man with humoral immunodeficiency, opportunistic infections, and recurrent EBV‐positive diffuse large B‐cell
Lucie Roussel, Stephane Bernier, Gertruda Evaristo, Anna Perez, Sanabelle Zaabat, Romina Pace, Yichun Sun, Isabelle Angers, John Storring, Donald C. Vinh   +9 more
wiley   +1 more source