Results 1 to 10 of about 64 (38)

SIRT7 suppresses the epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis by promoting SMAD4 deacetylation

Journal of Experimental and Clinical Cancer Research, 2018
Background Oral squamous cell carcinoma (OSCC) is one of the most common malignancies and has a poor prognosis. The epithelial-to-mesenchymal transition (EMT) is crucial for increasing the metastasis of OSCC.
Wenlu Li
exaly   +5 more sources

SIRT7 Deacetylates STRAP to Regulate p53 Activity and Stability

International Journal of Molecular Sciences, 2020
Serine-threonine kinase receptor-associated protein (STRAP) functions as a regulator of both TGF-β and p53 signaling that participates in the regulation of cell proliferation and cell death in response to various stresses.
Jianyuan Luo, Xiaoyan Qiu, Wengong Wang
exaly   +3 more sources

Sirtuin3 and Sirtuin7 are promising biomarkers in systemic sclerosis

Egyptian Rheumatology and Rehabilitation
Background Systemic sclerosis (SSc) is an autoimmune disease that results in micro-vasculopathy, leading to organ dysfunction. Sirtuins are known for their role in cellular processes such as the cell cycle, aging, and inflammation, Sirtuins also play an ...
Nihal Fathi, Yasmine Saad Makarem, Marwa Mahmoud Abdelaziz   +2 more
exaly   +3 more sources

Comprehensive succinylome analyses reveal that hyperthermia upregulates lysine succinylation of annexin A2 by downregulating sirtuin7 in human keratinocytes [PDF]

Journal of Translational Internal Medicine, 2023
Background and Objectives: Local hyperthermia at 44°C can clear multiple human papillomavirus (HPV)-infected skin lesions (warts) by targeting a single lesion, which is considered as a success of inducing antiviral immunity in the human body ...
Niu, Xueli, Zhao, Yiping, Li, Jingyi, Qi, Ruiqun, Wei, Zhendong, Tang, Mingsui, Chen, Hongduo, Wan, Wenyu, Fu, Kangle, Sun, Yuzhe, Gao, Xinghua, Zhang, Tao, Song, Bing   +12 more
core   +2 more sources

Sirtuin7 is involved in protecting neurons against oxygen-glucose deprivation and reoxygenation-induced injury through regulation of the p53 signaling pathway

Journal of Biochemical and Molecular Toxicology, 2017
Ya Zhang, Jianrui Lv, Guoxi Zheng
exaly   +3 more sources

p53 inhibition attenuates cisplatin-induced acute kidney injury through microRNA-142-5p regulating SIRT7/NF-κB

Renal Failure, 2022
Renal tubular epithelial cell apoptosis is the main mechanism of cisplatin-induced acute kidney injury. The role of microRNAs (miRNAs) in the apoptosis of renal tubular epithelial cells has been suggested, but the underlying mechanism has not been fully ...
Guoxiao Chen, Huanzhou Xue, Xiangsheng Zhang, Degang Ding, Shilong Zhang   +4 more
doaj   +2 more sources

Blood Differential Gene Expression in Patients with Chronic Heart Failure and Systemic Iron Deficiency: Pathways Involved in Pathophysiology and Impact on Clinical Outcomes [PDF]

Journal of Clinical Medicine, 2021
Background: iron deficiency is a common disorder in patients with heart failure and is related with adverse outcomes and poor quality of life. Previous experimental studies have shown biological connections between iron homeostasis, mitochondrial ...
Moliner, Pedro, Yun, Sergi, Carles Díez-López, Raul Ramos-Polo, Josep Comín-Colet, Díez López, Carles, García Romero, Elena, Comín Colet, Josep, José González-Costello, Ramos-Polo, Raúl, Jiménez Marrero, Santiago, González-Costello, José, Cristina Enjuanes Grau, Maria del Mar Ras Jiménez, Francesch Manzano, Josep, Marta Tajes Orduña, Enjuanes, Cristina, Ras Jiménez, Maria del Mar, Santiago Jiménez-Marrero, Tajes Orduña, Marta, Josep Francesch Manzano, Pedro Moliner Borja, Elena García-Romero, Sergi Yun Viladomat   +23 more
core   +2 more sources

H2O2 down-regulates SIRT7’s protective role of endothelial premature dysfunction via microRNA-335-5p

Bioscience Reports, 2022
Endothelial senescence is believed to constitute the initial pathogenesis of the atherosclerotic cardiovascular disease (ASCVD). MicroRNA-335-5p (miR-335-5p) expression is significantly up-regulated in oxidative stress-induced endothelial cells (ECs ...
Birong Dong, Birong Dong, Juelin Deng
exaly   +2 more sources

Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b

Hepatology, 2012
Sirtuins are nicotinamide adenine dinucleotide oxidized form (NAD+)‐dependent deacetylases and function in cellular metabolism, stress resistance, and aging.
Young Gyoon Chang, Suk Woo Nam, Kwang Hwa Jung, Jung Young Lee, Won Sang Park, Jeong Kyu Kim, Jung Woo Eun, Hyun Jin Bae, Jürgen Borlak, Ji Heon Noh, Qingyu Shen, Min Gyu Kim   +11 more
core   +2 more sources

Evaluation of the Level of Sirtuin7 and Some Biochemical Parameters in Patients with Cardiovascular Disease

International Journal for Scientific Research
The regulatory protein SIR7 Homolog 7 is known as sirtuin7 and is one of the seven most important sirtuins found in mammals, it is located primarily in the nucleus and is released from the nucleus into the nucleoplasm in response to stress.
Hiba Lazem, M. Hassin
exaly   +2 more sources