Results 211 to 220 of about 367,815 (295)

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Relative Sit-to-Stand Power Versus Conventional Sit-to-Stand Time in the Clinical Assessment of Older Adults at Risk of Falls. [PDF]

Healthcare (Basel)
Huertas-Hoyas E, Curiel-Regueros A, García-Molina R, García-De-Villa S, Rincón-Herrera E, Alonso-Bouzón C, Ruiz-Ruiz L, Jiménez-Ruiz AR, Neira-Álvarez M.   +8 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Automatic identification of postural transitions using a single inertial measurement unit and dynamic time warping: a pilot study in healthy individuals and people with Parkinson's disease. [PDF]

Front Bioeng Biotechnol
Amici C, Bussola R, Pollet J, Gobbo M, Buraschi R.   +4 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Enhancing sit-to-stand transitions and walking efficiency in older adults with a soft robotic suit. [PDF]

Nat Commun
Zhang X, Tricomi E, Stefanakis M, Gierden N, Buchner T, Mišković L, Bauer JM, Werner C, Becker C, Masia L.   +9 more
europepmc   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Open Cholecystectomy in a Patient With Situs Inversus Totalis and Symptomatic Cholelithiasis: A Case Report. [PDF]

Clin Case Rep
Gillani SFP, Javaid MH, Ali RN, Irfan W, Irfan S, Mahato RK.   +5 more
europepmc   +1 more source