Results 91 to 100 of about 5,793,670 (302)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Estimating Site Performance (ESP): can trial managers predict recruitment success at trial sites? An exploratory study

Trials, 2019
Background Multicentre randomised trials provide some of the key evidence underpinning healthcare practice around the world. They are also hard work and generally expensive.
Hanne Bruhn, Shaun Treweek, Anne Duncan, Kirsty Shearer, Sarah Cameron, Karen Campbell, Karen Innes, Dawn McRae, Seonaidh C. Cotton   +8 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The Wa\u27akas Site (41CP490) at Lake Bob Sandlin, Camp County, Texas [PDF]

, 2012
The Wa\u27akas site (meaning Cow in the Caddo language) is located on a small toe slope (330ft. amsl) overlooking a small and unnamed tributary to Big Cypress Creek. The channel of Big Cypress Creek lies about 1 km to the north. The toe slope landform is
Nelson, Bo, Perttula, Timothy K.
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Nested Bethe ansatz for Y(gl(n)) open spin chains with diagonal boundary conditions

, 2011
In this proceeding we present the nested Bethe ansatz for open spin chains of XXX-type, with arbitrary representations (i.e. `spins') on each site of the chain and diagonal boundary matrices $(K^+(u),K^-(u))$.
A. I. Molev, A. I. Molev, A. I. Molev, D. Arnaudon, D. Arnaudon, E. K. Sklyanin, E. Mukhin, E. Sklyanin, I. Cherednik, N. Yu. Reshetikhin, P. P. Kulish, S. Belliard, V. Chari, V. G. Drinfeld, V. G. Drinfeld, W. Galleas, É. Ragoucy   +16 more
core   +3 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Molecular structure of human KATP in complex with ATP and ADP

eLife, 2017
In many excitable cells, KATP channels respond to intracellular adenosine nucleotides: ATP inhibits while ADP activates. We present two structures of the human pancreatic KATP channel, containing the ABC transporter SUR1 and the inward-rectifier K ...
Kenneth Pak Kin Lee, Jue Chen, Roderick MacKinnon   +2 more
doaj   +1 more source

A Discrete Choice Model for Web Site Work Results [PDF]

Currently a corporate web site is not considered as a necessary business attribute, but as a marketing tool which should yield results. In this study we consider a web site as an instrument for attraction of new partners (customers, suppliers).
Pavlyuk, Dmitry
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source