Results 91 to 100 of about 5,811,187 (302)
Trials, 2019 Background Multicentre randomised trials provide some of the key evidence underpinning healthcare practice around the world. They are also hard work and generally expensive.
Hanne Bruhn +8 more
doaj +1 more source
Nested Bethe ansatz for Y(gl(n)) open spin chains with diagonal boundary conditions
, 2011 In this proceeding we present the nested Bethe ansatz for open spin chains of XXX-type, with arbitrary representations (i.e. `spins') on each site of the chain and diagonal boundary matrices $(K^+(u),K^-(u))$.
A. I. Molev +16 more
core +3 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Strong many-particle localization and quantum computing with perpetually coupled qubits
, 2004 We demonstrate the onset of strong on-site localization in a one-dimensional many-particle system. The localization is obtained by constructing, in an explicit form, a bounded sequence of on-site energies that eliminates resonant hopping between both ...
G. P. Berman +6 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Molecular structure of human KATP in complex with ATP and ADP
eLife, 2017 In many excitable cells, KATP channels respond to intracellular adenosine nucleotides: ATP inhibits while ADP activates. We present two structures of the human pancreatic KATP channel, containing the ABC transporter SUR1 and the inward-rectifier K ...
Kenneth Pak Kin Lee +2 more
doaj +1 more source
Semiparametric estimation of on-stie count data models [PDF]
This article proposes semiparametric estimation of on-site count data models based on a series expansion approach of Gurmu, Rilstone and Stern (1999, Journal of Econometrics 88, 123-150), which is flexible and adaptable for a form of overdispersion as ...
Katsuhito Nohara, Masaki Narukawa
core
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Discrete breathers in nonlinear network models of proteins
, 2007 We introduce a topology-based nonlinear network model of protein dynamics with the aim of investigating the interplay of spatial disorder and nonlinearity. We show that spontaneous localization of energy occurs generically and is a site-dependent process.
Juanico, Brice +3 more
core +5 more sources