Results 121 to 130 of about 1,531,150 (267)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Getting ready for inspection of investigational site at short notice
Perspectives in Clinical Research, 2010 India is becoming an attractive destination for drug development and clinical research. This is evidenced by the three fold increment in clinical trial applications in last four years to the office of Drugs Controller General of India (DCGI). This upward
Rajendra Talele
doaj
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Integrated analysis of energy, indoor environment, and occupant satisfaction in green buildings using real-time monitoring data and on-site investigation. [PDF]
Build Environ, 2020 Wang L, Zheng D.
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Querying Q fever: spatiotemporal patterns and environmental drivers in French Guiana
BMJ Global HealthBackground Q fever is a zoonotic infection caused by the bacterium Coxiella burnetii. French Guiana, largely covered by the Amazon rainforest, is considered a hyper-endemic region.
Mathieu Nacher +8 more
doaj +1 more source
Publicly funded cleanups site status report: SRP Report 1996
, 1996 The "Publicly Funded Cleanups Site Status Report" 1996 focuses on investigation, cleanup and monitoring progress by the New Jersey Department of Environmental Protection's (NJDEP) Site Remediation Program at contaminated sites being addressed with public
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Geotechnical investigation East Arm Port, NT
, 2003 This report presents the results of a geotechnical investigation carried out by Douglas Partners Pty Ltd (DP) at the site of reclamation works at the gatehouse ponds at the East Arm Port, Northern Territory.
Douglas Partners Pty Ltd
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source