Results 121 to 130 of about 3,496,435 (294)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Dielectric properties of Granodiorite partially saturated with water and its correlation to the detection of seismic electric signals

, 2011
Transient electric signals emitted prior to earthquake occurrence are recorded at certain sites in the Earth's crust termed sensitive. These field observations enforce the laboratory investigation of the dielectric response of rocks forming these ...
A.N. Papathanassiou, Endres, Fontanella, Fontanella, I. Sakellis, J. Grammatikakis, Morgan, Morgan, Nettelblad, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Papathanassiou, Surkov, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos, Varotsos   +38 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Predicting Geotechnical Investigation Using the Knowledge Based System

Advances in Fuzzy Systems, 2016
The purpose of this paper is to evaluate the optimal number of investigation points and each field test and laboratory test for a proper description of a building site.
Bojan Žlender, Primož Jelušič
doaj   +1 more source

A dedicated tool for a full 3D Cn2 investigation

, 2010
We present in this study a mapping of the optical turbulence (OT) above different astronomical sites. The mesoscale model Meso-NH was used together with the Astro-Meso-Nh package and a set of diagnostic tools allowing for a full 3D investigation of the ...
Hagelin, Susanna, Lascaux, Franck, Masciadri, Elena   +2 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Geotechnical performance of the Gounokawa River levee during the 2018, 2020, and 2021 flooding events

Soils and Foundations
Significant sand ejecta repeatedly appeared during the 2018, 2020, and 2021 flooding events at the Gounokawa River levee in the Shimonohara district of Shimane Prefecture, Japan.
Mitsu Okamura, Hirotoshi Mori, Masanori Ishihara, Kenichi Maeda, Naoko Jin-nouchi, Yudai Aoyagi, Shunsuke Shinagawa, Yoshinori Yajima, Kohei Ono   +8 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Study of the atmospheric conditions at Cerro Armazones using astronomical data

, 2016
Aims: We studied the precipitable water vapour (PWV) content near Cerro Armazones and discuss the potential use of our technique of modelling the telluric absorbtion lines for the investigation of other molecular layers.
Kausch, Wolfgang, Kerber, Florian, Kimeswenger, Stefan, Lakicevic, Masha, Noll, Stefan, Unterguggenberger, Stefanie   +5 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source