Results 221 to 230 of about 3,867,737 (309)

TPST Gene Knock-Out Eliminates Tyrosine Sulfation on a Recombinant Antibody Produced in CHO Cells. [PDF]

Biotechnol J
Schulman J, Egan R, Kandari L, Madayiputhiya N, Mahon D, Tao L, Luo H, Condon K, Feder JN, Huang D, Khetan A.   +10 more
europepmc   +1 more source

Distinct Cleavage Trajectories Mediated by DNA and RNA Substrate in Argonaute From Methanocaldococcus Fervens

Advanced Science, EarlyView.
This study characterizes MfAgo, an enzyme exhibiting highly efficient DNA‐guided DNA and RNA cleavage capability. Precise RNA cleavage strictly requires dimerization to stabilize the PIWI‐loop region, while its robust DNA cleavage functions in a dimerization‐independent manner.
Fuyong Huang, Taiyu Chen, Meng Fang, Qinmiao Duanmu, Kangle Mu, Yuqi Bi, Siwei Xu, Xin Tao, Jiening Wang, Shan Wu   +9 more
wiley   +1 more source

Climate warming shortens mast intervals by accelerating resource accumulation in the Northern Hemisphere

Chen L, Zhao Y, Gu H, Yang A, Qiu H, Wang L, Wang X, Hacket-Pain A, Bogdziewicz M.   +8 more
europepmc   +1 more source

Pan-European maps and models of current and future tree species distributions and their growth potential. [PDF]

Data Brief
Wöhlbrandt A, Onay A, Bachmann-Gigl U, Falk W, Temperli C, Aspalter S, Chakraborty D, Schüler S, Breidenbach J, Fridman J, Isaac-Renton M, Šebeň V, Skudnik M, Zlatanov T, Thom D, Thurm EA.   +15 more
europepmc   +1 more source

Hierarchical Flux‐Protection Engineering Stabilizes Oxidation‐Prone Metabolic Nodes for High‐Level Curcumin Biosynthesis

Advanced Science, EarlyView.
Flux‐protection engineering stabilizes an oxidation‐prone L‐DOPA node in engineered E. coli by combining acid‐adapted chassis evolution, respiratory‐chain modulation, enzyme‐level flux matching, and pH–DO control. Carbon is redirected from oxidative browning to productive biosynthesis, enabling 1075.2 mg/L curcumin and demonstrating transferability to ...
Jianbin Chen, Qihang Chen, Shurong Zhang, Yajuan Su, Xiaoyi Zou, Ke Wang, Shike Liu, Qian He, Liang Zhang, Weizhu Zeng, Jingwen Zhou   +10 more
wiley   +1 more source

Canada's Forests Are Shifting From a Recovery-Driven Carbon Sink to a Disturbance-Driven Carbon Source. [PDF]

Glob Chang Biol
Curasi SR, Melton JR, Humphreys ER, Arora VK, Beaver J, Cannon AJ, Chen JM, Hermosilla T, Lee SC, Wulder MA.   +9 more
europepmc   +1 more source

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

Advanced Science, EarlyView.
Targeted chimeric degraders engage extracellular or membrane proteins and endocytosable cell‐surface receptors, forming ternary complexes that induce receptor‐mediated internalization. Following endocytosis, post‐endocytic sorting—not internalization alone—determines target fate.
Ke Liu, Xiyan Wang, Xiaozhen Liu, Chaoqi He, Da Qian, Xuli Meng, Liquan Zhu   +6 more
wiley   +1 more source

Optimizing irrigation scheduling in apple orchards: soil moisture thresholds balance yield, fruit quality, and water use efficiency. [PDF]

Sci Rep
Nazir N, Nissar M, Nemali K, Malik AR, Malik A, Bhat R, Kumar A, Banday SA, Siddiqi NJ, Bisht C, Rasool S, Shah IA, Wani AW, Bhat TA.   +13 more
europepmc   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Drivers of spatial dynamics of a large ungulate (American Bison, <i>Bos bison</i>): forage productivity or site fidelity? [PDF]

J Mammal
Asmus KA, Kruse CG, Ranglack DH, Benson JF.   +3 more
europepmc   +1 more source