Results 171 to 180 of about 24,137,124 (342)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Carbon allocation across dominance classes varies with planting density, site quality, and climatic moisture deficit in <i>Cunninghamia lanceolata</i> plantations. [PDF]

Front Plant Sci
Lv Z, Trouvé R, Nitschke CR, Li X, Duan A, Zhang J.   +5 more
europepmc   +1 more source

Lessons from the on-site quality audit of data transmitted to the French cystic fibrosis registry. [PDF]

Orphanet J Rare Dis, 2018
Pellen N, Guéganton L, Pougheon Bertrand D, Rault G.   +3 more
europepmc   +1 more source

Top quality seminars on site [PDF]

British Dental Journal, 2013
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

How do stand age and site quality shape productivity of Chinese fir plantations via stand structural pathways? [PDF]

Front Plant Sci
Wang L, Han Y, Sun H, Zhang J.
europepmc   +1 more source

Outcome after Discontinuation of Proton Pump Inhibitors at a Residential Care Site: Quality Improvement Project. [PDF]

Can J Hosp Pharm, 2017
Lee C, Lo A, Ubhi K, Milewski M.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MEASURING QUALITY OF THE SERVICES PROVIDED BY THE COMMERCIAL WEB SITES [PDF]

The increasingly systematic usage of Internet in the decisional process of theconsumers determines the vendors to apply more frequently to the advantages of this instrument.A site must be before of all capable to answer the expectances of the consumers ...
Filimon Stremtan, Andreea Muntean
core  

Evaluating a Multi-Site Quality Improvement Intervention for Early Essential Newborn Care: Trends and Persistent Gaps Across Three Assessment Rounds in Viet Nam. [PDF]

Health Serv Insights
Tu Quyen BT, Thi Hoang Lan V, Van Chi N, Tuan HA, Tran H, Nga PQ, Lazzerini M, Yaqub NO.   +7 more
europepmc   +1 more source