Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Does the stoma site marking affect stoma quality?
Süleyman Demirel Üniversitesi Tıp Fakültesi DergisiObjective: Ostomy structure is an indispensable part of colorectal surgical procedures. With stoma, surgeons hope to get rid of the morbidity of the anastomosis they made. Ostomies are the source of morbidity both during construction and closure. Problem-
Salim İlksen Başçeken +4 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Evaluation of e-learning web sites using fuzzy axiomatic design based approach [PDF]
, 2009 High quality web site has been generally recognized as a critical enabler to conduct online business. Numerous studies exist in the literature to measure the business performance in relation to web site quality.
Arsenyan, Jbid +4 more
core +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Meta-analysis and systematic review of skin graft donor-site dressings with future guidelines. [PDF]
, 2018 Background: Many types of split-thickness skin graft (STSG) donor-site dressings are available with little consensus from the literature on the optimal dressing type. The purpose of this systematic review was to analyze the most recent outcomes regarding
Alwaal +58 more
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
A telephone assessment and advice service within an ED Physiotherapy clinic: A single-site quality improvement cohort study [PDF]
Arch Physiother, 2021 Kelly M +3 more
europepmc +2 more sources
COMPARISON OF ENVIRONMENTAL QUALITY-INDUCED DEMAND SHIFTS USING TIME-SERIES AND CROSS-SECTION DATA [PDF]
Almost all applications of the Travel-Cost-Method demand function which include site quality variable(s) are multisite models. The results of this study serve as a note of warning that using the demand equation derived from multisite cross-sectional data
Cooper, Joseph C., Loomis, John B.
core +1 more source
A Documentation and Analysis of Surdna Arts Teachers Fellowship Program (SATF): The First Decade 2000-2010 [PDF]
, 2011 Based on documents, interviews, and site visits, reviews the design and impact of a program to boost teaching and learning quality at public arts high schools by supporting teachers' artistic and professional development.
Mindy N. Levine
core