Results 171 to 180 of about 10,071,726 (310)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Clinicians' Perspectives on Pre-Anaesthetic Assessment and Their Attitudes Towards AI-Supported Models: Protocol for an International Survey of Anaesthesia Personnel. [PDF]

Acta Anaesthesiol Scand
Christiansen CTG, Nellemann M, Denneborg MKG, Bosholdt SA, Jakobsen JC, Hesselfeldt RT, Møller MH, Møgelmose A, Vogelius MK, Olsen MH, Buggeskov KB.   +10 more
europepmc   +1 more source

IS YIELD RESPONSE SITE-SPECIFIC? REVISITING NITROGEN RECOMMENDATIONS ON CORN [PDF]

Replaced with revised version of paper 08/19/02.Crop Production/Industries,
Swinton, Scott M., Miller, Neil R., Liu, Yanyan   +2 more
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Spotted fever group Rickettsia infection kinetics and cutaneous host response during single tick feeding events. [PDF]

PLoS Pathog
Suwanbongkot C, Langohr IM, Brewer KZ, Barrington RA, Macaluso KR.   +4 more
europepmc   +1 more source

Plan práctico apoyo-recuperación en el área de Ciencias 12-16

, 1990
Se realiza en Valladolid por el M.R.P Concejo Educativo-CEP-SITE, se centra en una serie de actividades que sirvan de apoyo para alumnos con dificultades en el área de Ciencias, especialmente en Física y Matemáticas.
Concejo Educativo-CEP-SITE
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Markers of Autonomic Function and Cancer Mortality Risk in Healthy Adults. [PDF]

JACC Adv
Meernik C, Leonard D, Shuval K, Barlow CE, Pavlovic A, Kamrudin S, Jones LW, Gabriel KP, Carter JR, Radford N, Berry JD, DeFina LF, Gilchrist SC.   +12 more
europepmc   +1 more source