Results 201 to 210 of about 10,071,726 (310)

Setting the standard: empirical benchmarks for case-level site-central discordance in radiographic endpoints in oncology clinical trials. [PDF]

Contemp Clin Trials Commun
Goldmacher GV, Goldberg CM, Boyle L, Jia L, Gause CK, Green MC, Schwartz LH.   +6 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Water Table and Vegetation Shape Peatland CO₂ and CH₄ Fluxes With Water Table Modulating Temperature Sensitivity. [PDF]

Glob Chang Biol
Chen H, Yotmaw J, Thompson L, Bittner D, Ren Y, Xu Y, Davidson SJ, Wei J, Yin W, Campbell G, Xue S, Evans CD, Smith P, Hastings A, Abdalla M.   +14 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Electronic structure reconstruction and low-energy optical response in La/Co-codoped BaTiO₃: a first-principles study. [PDF]

RSC Adv
Qiu J, Li C, Zhang C, Luo X.
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Bridging Electron Density Relaxation and XPS Spectroscopy: Orbital-Resolved Trends in Core-Ionized Aum (m = 4, 10, 20) and (TiO2)n (n = 2-4) Clusters. [PDF]

J Phys Chem A
Gostyński B.
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

The Next Frontier in Quantitative Co-Clinical Imaging to Advance Functional Precision Oncology. [PDF]

Clin Cancer Res
Shoghi KI, Badea CT, Peehl DM, Chenevert TL, Daldrup-Link HE, Hawkins DS, Houghton AM, Kinahan PE, Lewis MT, Ma CX, Manning HC, Miyaoka RS, Mowery YM, O'Connor JP, O'Dwyer PJ, Ross BD, Sriram R, Yankeelov TE, Zhou R, Kurhanewicz J, Mankoff DA.   +20 more
europepmc   +1 more source