Results 151 to 160 of about 30,097,494 (296)

Spotted fever group Rickettsia infection kinetics and cutaneous host response during single tick feeding events. [PDF]

PLoS Pathog
Suwanbongkot C, Langohr IM, Brewer KZ, Barrington RA, Macaluso KR.   +4 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Setting the standard: empirical benchmarks for case-level site-central discordance in radiographic endpoints in oncology clinical trials. [PDF]

Contemp Clin Trials Commun
Goldmacher GV, Goldberg CM, Boyle L, Jia L, Gause CK, Green MC, Schwartz LH.   +6 more
europepmc   +1 more source

Emergency Response Program

, 2013
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on March 31, 2014)"Last ...

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Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Baseline-Dependent Biological Response to Peri-Implant Soft Tissue Augmentation: A Secondary Analysis of a Randomized Clinical Trial. [PDF]

J Funct Biomater
Hadzik J, Kubasiewicz-Ross P, Romeo U, Kujawa K, Valente NA, Dominiak M.   +5 more
europepmc   +1 more source

Seismic site characterization and ground response analysis for an offshore site

Japanese Geotechnical Society Special Publication, 2015
T G, Sitharam, James, Naveen, Nayak, Monalisha   +2 more
openaire   +2 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Integrating NMR and contact-response analysis reveals the allosteric network driving domain closure in Enzyme I. [PDF]

Proc Natl Acad Sci U S A
Singh A, Burns D, Sedinkin SL, Das S, Potoyan DA, Venditti V.   +5 more
europepmc   +1 more source