Results 231 to 240 of about 2,905,224 (291)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Test site environmental conditions

Data to characterize the test site environmental conditions including metocean data (wave, wind and currents) as well as bathimetry, seabed conditions and other relevant information.Refers to task 4 ...
openaire   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Application of implementation science frameworks to a community-based healthy eating and activity intervention: a cross-sectional analysis. [PDF]

Front Health Serv
Tabak RG, Schwarz CD, Haire-Joshu D, Wang J, Gilbert A, Steger-May K.   +5 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Global Investigation of Clinical Implementation Strategies for DPYD Testing to Guide Fluoropyrimidine Therapy. [PDF]

Clin Transl Sci
El Rouby N, Aquilante CL, Bargal SA, Cavallari LH, Duarte JD, Gunderson K, Mazhindu T, Nagy M, Nie X, Nguyen DG, Patel JN, Skaar TC, Smith DM, Tuteja S, van Schaik RHN, Hicks JK, PGRN Implementation Working Group.   +16 more
europepmc   +1 more source

Quantitative Percussion Diagnostics (QPD): Seeing What the Eye Can't With Objective Structural Data. [PDF]

Cureus
Sheets CG, Earthman JC, Kurtzman GM.
europepmc   +1 more source

Utility of Targeted RNA Analysis in Neurogenetic Disorders. [PDF]

Neurol Genet
Ichikawa S, Yergert K, Gasser B, Towne MC, Burow D.   +4 more
europepmc   +1 more source

Using multi-method approaches to document and assess adaptations in a community-driven COVID-19 testing program. [PDF]

Implement Sci Commun
Salgin L, Reyes BJ, Bojorquez MB, Lomeli A, Velasquez S, Cain KL, Seifert M, Laurent LC, Stadnick NA, Rabin BA.   +9 more
europepmc   +1 more source

Better data for better predictions: data curation improves deep learning for sgRNA/Cas9 prediction. [PDF]

PeerJ
Browne TS, Edgell DR, Gloor GB.
europepmc   +1 more source