Results 181 to 190 of about 10,087,786 (356)

Decision letter for "Integrated regulation of the phosphatidylinositol cycle and phosphoinositide‐driven lipid transport at er‐pm contact sites"

, 2019

openalex   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Peat cutaway properties define after-use options and capacity for climate regulation. [PDF]

Environ Manage
Maanavilja L, Allonen O, Aro L, Sutinen H, Vähäkuopus T, Laine AM.   +5 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Cryptic Declines in a Widespread Australian Frog Complex. [PDF]

Ecol Evol
Crawford-Ash J, Pulsford S, Osborne W, Starrs D, Heard GW, Scheele BC.   +5 more
europepmc   +1 more source

Decision letter for "Novel <i>SBF1</i> splice-site null mutation broadens the clinical spectrum of Charcot-Marie-Tooth type 4B3 disease"

, 2018

openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Methylomic signatures of tau and amyloid-beta in transgenic mouse models of Alzheimer's disease neuropathology. [PDF]

NPJ Dement
Leung SK, Walker EM, Policicchio S, Dahir A, Vellame DS, Smith AR, Swarbrick R, Lunnon K, Dempster EL, Ahmed Z, Hannon E, Castanho I, Mill J.   +12 more
europepmc   +1 more source

The cultural significance of burial sites among Africans: a case study of Inanda.

, 2020
Nokuzola Ayanda. Ngcece
openalex   +1 more source

Faculty Opinions recommendation of Galanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptors.

, 2008
Titia K. Sixma
openalex   +2 more sources