PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Associations of different types of physical activity (PA) with musculoskeletal disorders (MSDs) at nine body sites in firefighters. [PDF]
Gan W +5 more
europepmc +1 more source
MARINe/PISCO: Intertidal: site temperature data: Hopkins, California (IHOPXX)
Multi-Agency Rocky Intertidal Network (MARINe) +2 more
openalex +1 more source
R@P: developing and promoting the Referencing@Portsmouth service [PDF]
Gwyer, Roisin +3 more
core
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
ADNP regulates chromatin architecture and lineage fidelity during neural differentiation. [PDF]
Wulfridge P +5 more
europepmc +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Spatial Analysis of <i>Astragalus verus</i> Olivier Dieback: Understanding Patterns and Implications for Conservation in Iranian Rangelands. [PDF]
Sheikhzadeh A +3 more
europepmc +1 more source

