Results 51 to 60 of about 2,185,547 (202)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

About what about: the semantics and syntax of irregular wh-questions in English

Linguistics, 2023
Although often used as diagnostic tools in discourse studies, irregular wh-questions in English, which take the form of what/how about … ? and what/how if … ?, have not received sufficient attention in terms of their semantic and syntactic properties ...
Li Wenshan, Liu Jiang
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Diversity-enhanced reconstruction as plug-in defenders against adversarial perturbations

Frontiers in Artificial Intelligence
Deep learning models are susceptible to adversarial examples. In large-scale deployed services, plug-in defenders efficiently defend against such attacks.
Zeshan Pang, Zeshan Pang, Xuehu Yan, Xuehu Yan, Shasha Guo, Shasha Guo, Yuliang Lu, Yuliang Lu   +7 more
doaj   +1 more source

Mapping Brain Activity During Loss of Situation Awareness: an EEG investigation of a basis for top-down influence on perception [PDF]

, 2014
Objective: The objective was to map brain activity during early intervals in loss of Situation Awareness (SA) to examine any co-activity in visual and high-order regions, reflecting grounds for top-down influences on level 1 SA.
Alford, Christopher A, Nikolla, Dritan, White, Sarah, Edgar, Graham, Alford, Chris, Baker, Steven, Catherwood, Diana, Brookes, David, Baker, Stephen, Catherwood, Dianne F, Edgar, Graham K   +10 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Situation of the Science Libraries in Argentine [PDF]

, 2000
The purpose of this work is to introduce the present-day situation of the Libraries of Science in the Argentine Republic, emphasising on there possibilities of access to information.
Gómez, Nancy-Diana
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source