Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
Protein Composition and Starch Structural Differentiation During Wheat Grain Filling Are Associated with Mature Grain Quality. [PDF]
Wang H +6 more
europepmc +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
From Nanoparticles to Microparticles in Plasma Electrolytic Oxidation: Transport, Incorporation, and Coating Performance. [PDF]
Bordbar-Khiabani A, Bahrampour S.
europepmc +1 more source
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
The community patterns and assembly mechanism varied in eukaryotic microorganisms with different cell sizes. [PDF]
Hu W +8 more
europepmc +1 more source
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen +5 more
wiley +1 more source
Joint morphological and DNA metabarcoding gut content analysis revealed that adult body size, but not biological sex, influences variance in dietary composition within and among cunner wrasse (<i>Tautogolabrus adspersus</i>) populations. [PDF]
Bender CJD, Moir CD, Boulding EG.
europepmc +1 more source
Synthesis of Titanium Carbide Powder by a Non-Vacuum Electric Arc Method and Fabrication of Porous Cermets. [PDF]
Kanapinov M +3 more
europepmc +1 more source
Lipid Cargo of Small Extracellular Vesicles as a Novel Contributor to Cardiovascular Diseases. [PDF]
Keene C, Knudsen L, Liaw L, Pinz IM.
europepmc +1 more source

